-
Article
Open AccessA pathogenic PSEN1 Trp165Cys mutation associated with early-onset Alzheimer’s disease
Presenilin-1 (PSEN1) is one of the causative genes for early onset Alzheimer’s disease (EOAD). Recently, emerging studies reported several novel PSEN1 mutations among Asian. We describe a male with EOAD had a ...
-
Article
Novel GRN mutations in Koreans with Alzheimer’s disease
Backgrounds Alzheimer’s disease (AD) and fronto-temporal dementia (FTD) are the two most common neurodegenerative diseases leading to early onset dementia (<65 years). Mutations in the amyloid precursor protein, ...
-
Article
Open AccessGenetic analyses of early-onset Alzheimer’s disease using next generation sequencing
Alzheimer’s disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly understood. Many mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN1 ...
-
Article
Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media
The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environme...
-
Article
Clinical genetic strategies for early onset neurodegenerative diseases
Methods for the genetic diagnosis of neurodegenerative disorders were reviewed, including their backgrounds and applications in the laboratory. Majority of disease-causing gene mutations were uncommon in the g...
-
Article
Open AccessMultiplex PCR for simultaneous identification of E. coli O157:H7, Salmonella spp. and L. monocytogenes in food
The rapid detection of pathogens in food is becoming increasingly critical for ensuring the safety of consumers, since the majority of food-borne illnesses and deaths are caused by pathogenic bacteria. Hence, ...
-
Article
Open AccessA novel multiplex PCR method for the detection of virulence-associated genes of Escherichia coli O157:H7 in food
Shiga toxin-producing Escherichia coli O157:H7 (E. coli O157:H7) strains are foodborne infectious agents that cause a number of life-threatening diseases, including hemorrhagic colitis (HC) and hemolytic uremic s...
-
Article
Erratum to: Gene panels and primers for next generation sequencing studies on neurodegenerative disorders
-
Article
Optimization of specific multiplex DNA primers to detect variable CLU genomic lesions in patients with Alzheimer’s disease
Recently, polymorphisms in the clusterin (CLU) or Apolipoprotein J (ApoJ) gene were reported to be involved in lipid metabolism, atherogenesis, and being associated with the risk of develo** Alzheimer’s disease...
-
Article
Gene panels and primers for next generation sequencing studies on neurodegenerative disorders
Several types of neurodegenerative diseases were described, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), prion disease, and Parkinson’s disease (PD). ...
