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  1. Article

    Open Access

    Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

    Metastasis arises from disseminated tumour cells (DTCs) that are characterized by intrinsic phenotypic plasticity and the capability of seeding to secondary organs. DTCs can remain latent for years before givi...

    Daniela Michelatti, Sven Beyes, Chiara Bernardis, Maria Luce Negri… in Nature Communications (2024)

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    Quantitative Analysis of PcG-Associated Condensates by Stochastic Optical Reconstruction Microscopy (STORM)

    The polycomb group (PcG) proteins play a central role in the maintenance of a repressive state of gene expression. Recent findings demonstrate that PcG components are organized into nuclear condensates, contri...

    Silvia Scalisi, Ali Ahmad, Sarah D’Annunzio, David Rousseau… in Polycomb Group Proteins (2023)

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    Article

    MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome

    The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin compartments include transcriptional clusters whose dynamic establishment and funct...

    Alessandra Fasciani, Sarah D’Annunzio, Vittoria Poli, Luca Fagnocchi… in Nature Genetics (2020)