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  1. Article

    Open Access

    Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

    Metastasis arises from disseminated tumour cells (DTCs) that are characterized by intrinsic phenotypic plasticity and the capability of seeding to secondary organs. DTCs can remain latent for years before givi...

    Daniela Michelatti, Sven Beyes, Chiara Bernardis, Maria Luce Negri… in Nature Communications (2024)

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  2. No Access

    Article

    LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion

    How gene expression is controlled to preserve human T cell quiescence is poorly understood. Here we show that non-canonical splicing variants containing long interspersed nuclear element 1 (LINE1) enforce naiv...

    Federica Marasca, Shruti Sinha, Rebecca Vadalà, Benedetto Polimeni… in Nature Genetics (2022)