10 Result(s)
within
Sara Hernando-Amado
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Article
Role of bacterial multidrug efflux pumps during infection
Multidrug efflux pumps are protein complexes located in the cell envelope that enable bacteria to expel, not only antibiotics, but also a wide array of molecules relevant for infection. Hence, they are importa...
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Article
Open AccessMutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance
Mutations in mexZ, encoding a negative regulator of the expression of the mexXY efflux pump genes, are frequently acquired by Pseudomonas aeruginosa at early stages of lung infection. Although traditionally relat...
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Protocol
The Pseudomonas aeruginosa Resistome: Permanent and Transient Antibiotic Resistance, an Overview
One of the most concerning characteristics of Pseudomonas aeruginosa is its low susceptibility to several antibiotics of common use in clinics, as well as its facility to acquire increased resistance levels. Cons...
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Article
Translating eco-evolutionary biology into therapy to tackle antibiotic resistance
Antibiotic resistance is currently one of the most important public health problems. The golden age of antibiotic discovery ended decades ago, and new approaches are urgently needed. Therefore, preserving the ...
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Article
Open AccessTackling antibiotic resistance by inducing transient and robust collateral sensitivity
Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the possibility that this c...
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Chapter
Antibiotic Resistance in Pseudomonas
Pseudomonas is a bacterial genus, with a bona fide environmental habitat that comprises different species, some of them causing diseases in humans and plants, as well as some strains with biotechnological potenti...
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Article
Defining and combating antibiotic resistance from One Health and Global Health perspectives
Several interconnected human, animal and environmental habitats can contribute to the emergence, evolution and spread of antibiotic resistance, and the health of these contiguous habitats (the focus of the One...
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Article
Prediction of the intestinal resistome by a three-dimensional structure-based method
The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic elements. Yet, this ...
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Article
Open AccessThe family of DOF transcription factors in Brachypodium distachyon: phylogenetic comparison with rice and barley DOFs and expression profiling
Transcription factors (TFs) are proteins that have played a central role both in evolution and in domestication, and are major regulators of development in living organisms. Plant genome sequences reveal that ...
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Article
Structure, expression profile and subcellular localisation of four different sucrose synthase genes from barley
Genes encoding two new isoforms of sucrose synthase from barley, HvSs3 and HvSs4, have been characterised and their expression patterns compared with those previously described for HvSs1 and HvSs2, in different o...
