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Chapter
BRCA and Breast Cancer-Related High-Penetrance Genes
Genetic susceptibility explains 5–10% of all breast cancer cases. High-penetrance breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast cancer. BRCA1 and BRCA2 genes are the...
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Article
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
The receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 play important roles in necroptosis that are closely linked to the inflammatory response. Although the activation of necroptosis is wel...
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Article
WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation
Oncogene-induced senescence (OIS) or apoptosis through the DNA-damage response is an important barrier of tumorigenesis. Overcoming this barrier leads to abnormal cell proliferation, genomic instability, and c...
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Article
Open AccessSurgical outcomes of robotic thyroidectomy vs. conventional open thyroidectomy for papillary thyroid carcinoma
The purpose of this study was to compare the surgical outcomes of robotic thyroidectomy (RT) using bilateral axillo-breast approach (BABA) with conventional open thyroidectomy (OT) in papillary thyroid carcino...
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Article
Solitary fibrous tumor of the breast: a case report and review of the literature
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can be benign or malignant. SFTs have been most often documented in the pleura. Recently, involvement of extrapleural sites such as the abdome...
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Article
The prevalence and spectrum of BRCA1 and BRCA2 mutations in Korean population: recent update of the Korean Hereditary Breast Cancer (KOHBRA) study
The Korean Hereditary Breast Cancer (KOHBRA) study was established to evaluate the prevalence and spectrum of BRCA1/2 mutations in Korean breast cancer patients at risk for hereditary breast and ovarian cancer. A...
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Article
The Protective Effect of Parity in Hormone Receptor-Positive, Ki-67 Expressing Breast Cancer
Epidemiologic studies showed that the experience of pregnancy is associated with a reduced risk of breast cancer. We hypothesized that parity may differentially be associated with the development of invasive ...
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Article
The prevalence of BRCA mutations among familial breast cancer patients in Korea: results of the Korean Hereditary Breast Cancer study
The primary aim of this study was to estimate the prevalence of BRCA1/2 mutations among familial breast cancer (BC) patients in Korea. We analyzed 775 familial BC patients who were enrolled in the Korean Heredita...
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Article
Complementary and alternative medicine use and assessment of quality of life in Korean breast cancer patients: a descriptive study
The worldwide use of complementary and alternative medicine (CAM) among cancer patients has increased, with breast cancer patients being more likely to use CAM compared with any other cancer patients. However,...
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Article
Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer
Improved survival in patients with stage III colon cancer after a laparoscopic colectomy (LC) has been reported by Lacy et al. (Lancet 359:2224–2229, 6), and preserved immunity was suggested as the reason for the...