16 Result(s)
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Article
Open AccessThe foundations of the working alliance in assertive community treatment teams
In this study, we aimed to identify and define the fundamental components of the working alliance in multidisciplinary (Flexible) Assertive Community Treatment teams with shared caseloads, in order to support ...
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Article
Open AccessMentalization and Psychosis: A Rationale for the Use of Mentalization Theory to Understand and Treat Non-affective Psychotic Disorder
Social functioning can be severely impaired in non-affective psychotic disorder (NAPD). Current models of psychosis pathogenesis do not tend to focus on social dysfunction and pharmacological treatment fails t...
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Article
Open AccessGenome-wide expression and response to exposure-based psychological therapy for anxiety disorders
Exposure-based psychological treatments for anxiety have high efficacy. However, a substantial proportion of patients do not respond to therapy. Research examining the potential biological underpinnings of the...
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Article
Open AccessMetacognitive Reflection and Insight Therapy (MERIT) with a Patient with Persistent Negative Symptoms
Metacognition comprises a spectrum of mental activities involving thinking about thinking. Metacognitive impairments may sustain and trigger negative symptoms in people with schizophrenia. Without complex idea...
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Article
Open AccessPeripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid
The blood–brain barrier separates circulating blood from the central nervous system (CNS). The scope of this barrier is not fully understood which limits our ability to relate biological measurements from peri...
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Article
Open AccessElevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction
Myocardial infarction (MI) induces an inflammatory response in which neutrophils fulfill a prominent role. Mean neutrophil volume (MNV) represents the average size of the circulating neutrophil population. Our...
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Het Reumafonds en de reumapatiëntenverenigingen
Het Reumafonds is er voor bijna twee miljoen Nederlanders met een vorm van reuma. Het kan gaan om reumatoïde artritis, artrose of een van de overige honderd chronische aandoeningen aan gewrichten, spieren en p...
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Article
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid
Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype–phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) cons...
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Article
Common variant at 16p11.2 conferring risk of psychosis
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as m...
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Article
Open AccessMonitoring cardiac fibrosis: a technical challenge
The heart contains a collagen network that contributes to the contractility of the heart and provides cardiac strength. In cardiac diseases, an increase in collagen deposition is often observed. This fibrosis ...
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Article
A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer
Comparing normal colorectal mucosa and adenomas focusing on deregulated pathways obtains insight into the biological processes of early colorectal carcinogenesis. Publicly available microarray expression data ...
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Article
Network analysis of positional candidate genes of schizophrenia highlights myelin-related pathways
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Article
Arginine metabolism in a small animal model of sepsis and after hemihepatectomy
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Article
Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid
Nitric oxide (NO) may play a role in the pathophysiology of Alzheimer's disease (AD). Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, is involved in regulation of NO production. Re...
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Article
Effects of dietary coconut oil, butter and safflower oil on plasma lipids, lipoproteins and lathosterol levels
Objective: The aim of this present study was to determine plasma levels of lathosterol, lipids, lipoproteins and apolipoproteins during diets rich in butter, coconut fat and safflower oil.
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Article
Topoisomerases, New Targets in Cancer Chemotherapy
The enzymes involved in the regulation of the three-dimensional structure of DNA, topoisomerase I and II, are important for the handling of DNA during vital cellular processes such as translation, transcriptio...
