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Article
The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERα-positive breast cancer
The DEAD-box RNA helicases p68 (DDX5) and p72 (DDX17) have been shown to act as transcriptional co-activators for a diverse range of transcription factors, including oestrogen receptor-α (ERα). Here, we show t...
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Article
Erratum: Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-α and the transcriptional repressor PLZF
Correction to: Gene Therapy (2005) 12, 452–460. doi:10.1038/sj.gt.3302421 The above affiliations for the below authors were published incorrectly, the correct affiliations are given below: N Patel3, S Shousha2...
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Article
Erratum: Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-α and the transcriptional repressor PLZF
Correction to: Gene Therapy (2005) 12, 452–460. doi:10.1038/sj.gt.3302421 The above author name was published incorrectly, the correct name is given below: N Sarwar The publishers apologise for this error.
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Article
Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-α and the transcriptional repressor PLZF
Estrogen receptor α (ERα) is a ligand-inducible transcription factor that acts to regulate gene expression by binding to palindromic DNA sequence, known as the estrogen response element, in promoters of estrog...
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Article
Open AccessPurified malignant mammary epithelial cells maintain hormone responsiveness in culture
Currently, the therapy for breast cancer is determined by immunohistochemical staining of the primary tumour for oestrogen receptor alpha (ERα). However, a proportion of ERα-positive patients fail to respond to t...
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Article
Open AccessFibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer
Fibroblast growth factor 8 can transform NIH3T3 cells and its expression has been found to be associated with breast and prostate cancer. Following our finding that fibroblast growth factor 8 mRNA expression i...
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Article
Open AccessPrimary tumour characteristics and axillary lymph node status in breast cancer
This paper examines the correlation between axillary lymph node status and primary tumour characteristics in breast cancer and whether this can be used to select patients for axillary lymphadenectomy. The resu...
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Article
Breast carcinoma in women under the age of 50: Relationship between p53 immunostaining, tumour grade, and axillary lymph node status
There is evidence to suggest that breast carcinoma in young women behaves in a more aggressive manner than in older women. As positive immunostaining for p53 has also been associated with increased tumour aggr...
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Article
Down-regulation of a novel form of fibroblast growth factor receptor 1 in human breast cancer
Monoclonal antibodies against two epitopes of FGFR-1 have been used to investigate FGFR-1 expression in the normal and neoplastic human breast. Different forms are detected in the different cell types constitu...
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Article
The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue
Acidic fibroblast growth factor (FGF1) and two of its receptors, FGFR1 and FGFR4, were localized in cryostat sections of normal, benign and malignant human breast tissue by immunohistochemistry. Without pretre...
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Article
Presence of exon 5-deleted oestrogen receptor in human breast cancer: functional analysis and clinical significance
A variant form of the human oestrogen receptor (ER) mRNA lacking sequences encoded within exon 5 has been described (Fuqua SAW, Fitzgerald SD, Chamness GC, Tandon AK, McDonnell DP, Nawaz Z, O'Malloy BW, McGuir...
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Article
Fibroblast growth factor 2 in breast cancer: occurrence and prognostic significance
This paper examines the expression of fibroblast growth factor 2 (FGF-2) in the malignant human breast. Semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to assess the level of...
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Article
Keratin 19 mRNA measurement to detect micrometastases in lymph nodes in breast cancer patients
We have used polymerase chain reaction (PCR) to measure keratin 19 mRNA in order to detect breast cancer cells invading axillary lymph nodes. In a consecutive series of 125 patients with primary breast cancer,...
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Article
Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast
In this study, we used immunohistochemical and biochemical analysis to show that gp200-MR6, a 200 kDa molecule that is functionally associated with the human interleukin 4 (IL-4) receptor complex, is expressed...
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Article
Oesophageal and gastric carcinoma in the Republic of Yemen
We conducted a preliminary survey on 3064 patients who underwent upper gastrointestinal endoscopy at the Al-Thawra Hospital in Sana'a, Republic of Yemen, between January and December 1991. The age/sex distribu...
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Article
Immunohistochemical localisation of pS2 protein in ductal carcinoma in situ and benign lesions of the breast
The expression of pS2 was examined histochemically in paraffin sections taken from biopsy material from patients diagnosed with ductal carcinoma in situ (DCIS). Often intense immunoreactivity, to an anti-pS2 m...
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Article
Isolation of a lactoferrin cDNA clone and its expression in human breast cancer
A cDNA library constructed from mRNA from a human breast carcinoma metastasis was screened with a polyclonal antibody to deglycosylated human milk fat globule membrane, resulting in the isolation of eight clon...
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Chapter
Histopathology of Breast Carcinoma and Related Conditions
Carcinoma is a malignant tumor derived from epithelial cells. In the breast, epithelial cell line ducts, and acini or lobules. In these sites malignant transformation is indicated microscopically by the presen...
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Article
Orcein staining of leukocytes
An Orcein staining method has been developed which stains mature and immature leukocytes in blood films and bone-marrow smears. Two different patterns of staining are obtained depending on whether staining is ...
