Abstract
Carcinoma is a malignant tumor derived from epithelial cells. In the breast, epithelial cell line ducts, and acini or lobules. In these sites malignant transformation is indicated microscopically by the presence of morphological changes within the individual cells and by the way in which these cells are arranged in relationship to each other. As long as the proliferating malignant cells are present within the confinement of the basement membrane surrounding the ducts, acini, or the covering surface epithelium of the nipple, the tumor is considered an in situ carcinoma. When the basement membrane is breached and the malignant cells are seen infiltrating the breast stroma and tissue spaces, the tumor becomes an invasive carcinoma. The tumor cells in both in situ and invasive carcinoma may be arranged in a variety of ways or exhibit specific features, and these are used in providing the basis for the histological classification of breast carcinoma.
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© 1989 Springer-Verlag Berlin Heidelberg
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Shousha, S. (1989). Histopathology of Breast Carcinoma and Related Conditions. In: Hoogstraten, B., Burn, I., Bloom, H.J.G. (eds) Breast Cancer. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83675-6_2
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DOI: https://doi.org/10.1007/978-3-642-83675-6_2
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