39 Result(s)

Article

A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer

Preclinical studies have shown that the vitamin D analogue EB 1089 has significantly less calcaemic activity than its parent compound 1,25-dihydroxyvitamin D (1,25(OH)2D3) and significant anti-tumour activity....

T Gulliford, J English, KW Colston, P Menday, S Moller… in British Journal of Cancer (1998)

Article

Endothelial cell transfection with cationic liposomes and herpes simplex-thymidine kinase mediated killing

Endothelial cells are a promising target for cancer gene therapy because neoangiogenesis is vital for the supply of oxygen and nutrients to solid tumours. However, endothelial cells have been reported to be di...

K Fife, M Bower, RG Cooper, L Stewart, CJ Etheridge, RC Coombes, L Buluwela… in Gene Therapy (1998)

Article

Down-regulation of a novel form of fibroblast growth factor receptor 1 in human breast cancer

Monoclonal antibodies against two epitopes of FGFR-1 have been used to investigate FGFR-1 expression in the normal and neoplastic human breast. Different forms are detected in the different cell types constitu...

C Yiangou, H Cox, GS Bansal, R Coope, JJ Gomm, R Barnard… in British Journal of Cancer (1997)

Article

Keratin 19 mRNA is detectable by RT-PCR in lymph nodes of patients without breast cancer-reply

A Schoenfeld, RC Coombes in British Journal of Cancer (1997)

Article

Idoxifene is equipotent to tamoxifen in inhibiting mammary carcinogenesis but forms lower levels of hepatic DNA adducts

Tamoxifen is an effective agent preventing mammary carcinogenesis in rats but causing liver tumours. Idoxifene is a more potent antioestrogen and is effective in patients with advanced breast cancer. We theref...

P Pace, M Jarman, D Phillips, A Hewer, J Bliss, RC Coombes in British Journal of Cancer (1997)

Article

Expression of keratinocyte growth factor and its receptor in human breast cancer

The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammo...

GS Bansal, HC Cox, S Marsh, JJ Gomm, C Yiangou, Y Luqmani… in British Journal of Cancer (1997)

Article

The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue

Acidic fibroblast growth factor (FGF1) and two of its receptors, FGFR1 and FGFR4, were localized in cryostat sections of normal, benign and malignant human breast tissue by immunohistochemistry. Without pretre...

RC Coope, PJ Browne, C Yiangou, GS Bansal, J Walters, N Groome… in British Journal of Cancer (1997)

Article

Fibroblast growth factor 2 in breast cancer: occurrence and prognostic significance

This paper examines the expression of fibroblast growth factor 2 (FGF-2) in the malignant human breast. Semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to assess the level of...

C Yiangou, JJ Gomm, RC Coope, M Law, YA Luqmani, S Shousha… in British Journal of Cancer (1997)

Article

Keratin 19 mRNA measurement to detect micrometastases in lymph nodes in breast cancer patients

We have used polymerase chain reaction (PCR) to measure keratin 19 mRNA in order to detect breast cancer cells invading axillary lymph nodes. In a consecutive series of 125 patients with primary breast cancer,...

A Schoenfeld, Y Luqmani, HD Sinnett, S Shousha, RC Coombes in British Journal of Cancer (1996)

Article

Assessment of the effect of pretreatment with neoadjuvant therapy on primary breast cancer

Patients with invasive cancer of the breast (T1-4, N0-2, M0) were assigned to pretreatment based on oestrogen receptor (ER) status; patients with ER-negative tumours received chemotherapy [mitozantrone, methot...

J-C Gazet, RC Coombes, HT Ford, M Griffin, C Corbishley… in British Journal of Cancer (1996)

Article

Therapeutic effects of the aromatase inhibitor fadrozole hydrochloride in advanced breast cancer

The endocrine and therapeutic effects of the aromatase inhibitor fadrozole hydrochloride have been assessed in 80 post-menopausal patients with recurrent breast cancer after tamoxifen failure. Treatment alloca...

HR Bonnefoi, IE Smith, M Dowsett, PF Trunet, SJ Houston… in British Journal of Cancer (1996)

Article

Expression of fibroblast growth factor 1 is lower in breast cancer than in the normal human breast

We have measured the amount of fibroblast growth factor 1 (FGF-1) mRNA and protein in primary breast cancers and non-malignant breast tissue and have found greatly reduced levels in breast cancer compared with...

GS Bansal, C Yiangou, RC Coope, JJ Gomm, YA Luqmani… in British Journal of Cancer (1995)

Article

Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours

Limonene, a monocyclic monoterpene, occurs naturally in orange peel oil. It has been shown to exhibit both chemopreventive and chemotherapeutic activity without toxicity in rodent models. In this study we exam...

SK Chander, AGB Lansdown, YA Luqmani, JJ Gomm, RC Coope… in British Journal of Cancer (1994)

Article

Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma

Oestrone sulphatase is an important source of local synthesis of biologically active oestrogens in human breast cancer. The oestrone sulphatase enzyme in the particulate fraction of human breast carcinoma was ...

TRJ Evans, MG Rowlands, M Law, RC Coombes in British Journal of Cancer (1994)

Article

The prognostic significance of transforming growth factors in human breast cancer

Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the...

PA Murray, P Barrett-Lee, M Travers, Y Luqmani, T Powles… in British Journal of Cancer (1993)

Article

Immunohistochemical localisation of pS2 protein in ductal carcinoma in situ and benign lesions of the breast

The expression of pS2 was examined histochemically in paraffin sections taken from biopsy material from patients diagnosed with ductal carcinoma in situ (DCIS). Often intense immunoreactivity, to an anti-pS2 m...

YA Luqmani, T Campbell, S Soomro, S Shousha, MC Rio… in British Journal of Cancer (1993)

Article

CA-125 is not a useful marker in metastatic breast cancer

MJ Seckl, GJS Rustin, RC Coombes in British Journal of Cancer (1992)