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  1. No Access

    Article

    The protein content and morphogenesis of zymogen granules

    When zymogen granules, the secretion granules of pancreatic acinar cells, fill, secretory product is accumulated in immature granules, condensing vacuoles. Mature granules are formed when this product (protein...

    K. K. Goncz, R. Behrsing, S. S. Rothman in Cell and Tissue Research (1995)

  2. No Access

    Chapter and Conference Paper

    Following Protein Transport with the High Resolution X-Ray Microscope

    We had planned originally to present a broad overview of applications of x-ray microscopy to biological problems in this paper. However, recent progress from our group that provides an excellent demonstration ...

    S. S. Rothman, K. K. Goncz, B. W. Loo Jr. in X-Ray Microscopy III (1992)

  3. No Access

    Chapter

    Progress and Prospects in Soft X-Ray Holographic Microscopy

    The majority of x-ray imaging experiments currently use the contact technique or x-ray analogues of the optical microscope, either in direct imaging or scanning mode, as described in Chapters 4−6. It is also p...

    M. R. Howells, C. Jacobsen, J. Kirz, K. McQuaid, S. S. Rothman in Modern Microscopies (1990)

  4. No Access

    Chapter and Conference Paper

    The Biology of the Cell and the High Resolution X-Ray Microscope

    The biologist’s dream is to observe cellular structure and content by natural contrast mechanisms and, if possible, to observe variations as a natural consequence of cell function. While the x-ray microscope w...

    S. S. Rothman, N. Iskander, K. Mcquaid, H. Ade, D. T. Attwood… in X-Ray Microscopy II (1988)

  5. No Access

    Chapter

    The Biological Functions and Physiological Effects of Ingested Inhibitors of Digestive Reactions

    In terms of everyday experience, we think of disease and illness as something visited upon a healthy body from the outside; analogous to an unfortunate accident. Microbes infect us, and plagues and epidemics c...

    S. S. Rothman in Nutritional and Toxicological Significance of Enzyme Inhibitors in Foods (1986)

  6. No Access

    Article

    Zymogen granules of pancreas decrease in size in response to feeding

    In the first descriptions of pancreatic enzyme secretion about 100 years ago, it was noticed that zymogen granules became smaller and disappeared from the apical region of acinar cells after feeding. We have r...

    Dr. Thomas H. Ermak, S. S. Rothman in Cell and Tissue Research (1981)

  7. No Access

    Article

    Enteropancreatic circulation of digestive enzyme as a conservation mechanism

    THE permeability of the intestine to pancreatic digestive enzymes has been known for some years1–7. Recently it was demonstrated8 that chymotrypsinogen and amylase are transported across the pancreatic acinar cel...

    HERMANN GÖTZE, S. S. ROTHMAN in Nature (1975)

  8. No Access

    Article

    “Non-parallel Transport” of Enzyme Protein by the Pancreas

    Pancreozymin differentially enhances the secretion of trypsinogen and chymotrypsinogen by an in vitro pancreas. This may suggest selective secretion of these enzymes.

    S. S. ROTHMAN in Nature (1967)

  9. No Access

    Article

    Exocrine Secretion from the isolated Rabbit Pancreas

    STUDY of the mechanisms of secretion of the digestive glands has been handicapped by an inability to isolate the glands from the influence of variable control mechanisms such as blood flow, nervous factors and...

    S. S. ROTHMAN in Nature (1964)