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  1. No Access

    Article

    Isolation of CF cell lines corrected at ΔF508-CFTR locus by SFHR-mediated targeting

    Cystic fibrosis is the most common inherited disease in the Caucasian population. About 70% of all CF chromosomes carry the ΔF508 mutation, a 3-bp deletion that results in the loss of a phenylalanine at amino ...

    E Bruscia, F Sangiuolo, P Sinibaldi, K K Goncz, G Novelli, D C Gruenert in Gene Therapy (2002)

  2. No Access

    Article

    Application of SFHR to gene therapy of monogenic disorders

    Gene therapy treatment of disease will be greatly facilitated by the identification of genetic mutations through the Human Genome Project. The specific treatment will ultimately depend on the type of mutation ...

    K K Goncz, N L Prokopishyn, B L Chow, B R Davis, D C Gruenert in Gene Therapy (2002)

  3. No Access

    Article

    The protein content and morphogenesis of zymogen granules

    When zymogen granules, the secretion granules of pancreatic acinar cells, fill, secretory product is accumulated in immature granules, condensing vacuoles. Mature granules are formed when this product (protein...

    K. K. Goncz, R. Behrsing, S. S. Rothman in Cell and Tissue Research (1995)

  4. No Access

    Chapter and Conference Paper

    Following Protein Transport with the High Resolution X-Ray Microscope

    We had planned originally to present a broad overview of applications of x-ray microscopy to biological problems in this paper. However, recent progress from our group that provides an excellent demonstration ...

    S. S. Rothman, K. K. Goncz, B. W. Loo Jr. in X-Ray Microscopy III (1992)