Abstract
We had planned originally to present a broad overview of applications of x-ray microscopy to biological problems in this paper. However, recent progress from our group that provides an excellent demonstration of the utility of x-ray microscopy for research in biology, has changed our mind. The observations we have made, to our knowledge the first report of time-resolved structural change within single biological structures at high resolution, now form the focus of this presentation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
S.S. Rothman, N Iskander, D. Attwood, Y. Vladimirsky, K. McQuaid, J. Grendell, J. Kirz, H. Ade, I. McNulty, D. Kern, T.H.P. Chang, and H. Rarback, Biochim. Biophys. Acta 991, 484 (1989).
Howells, M., C. Jacobsen, J. Kirz, R. Feder, K. McQuaid, and S.S. Rothman. Science, 238: 514–517, 1987
Jacobsen, C., J. Kitz, M. Howells, K. McQuaid, S. Rothman, R. Feder and D. Sayre. In: X-ray Microscopy II, eds. D. Sayre, M. Howells, J. Kirz, and H. Rarback, Springer-Verlag, Berlin, 1988, pp. 253–262
Jacobsen, C., J. Kirz, M. Howells and S. Rothman. J. Optic. Soc. Amer. A, in press.
Rothman, S.S., N. Iskander, K. McQuaid, H. Ade, D.T. Attwood, T.H.P. Chang, J.H. Grendell, D.P. Kern, J. Kirz, I. McNulty, H. Rarback, D. Shu, and Y.Vladimirsky. In: X-ray Microscopy H, eds. D. Sayre, M. Howells, J. Kirz, and H. Rarback, Springer—Verlag, Berlin, 1988, pp. 372–377
Rarback, H., D. Shu, S.C. Feng, H. Ade, J. Kirz, I. McNulty, D.P. Kern, T.H.P.Chang, Y. Vladimirsky, N. Iskander, D. Attwood, K. McQuaid, and S.S.Rothman. Rev. Sci..Instrum., 59: 52–59, 1988
Vladimirsky, Y., D. Kern, P. Chang, D. Attwood, N. Iskander, S. Rothman, K. McQuaid, J. Kirz, H. Ade, I. McNulty, H. Rarback, and D. Shu. Nucl. Instrum. Meth., A266: 324–328, 1988.
Blobel, G. and Dobberstein, B. (1975) J. Cell Biol. 67, 835–851.
Liebow, C. and Rothman, S.S. (1972) Nature 241, 176–178.
Schatz, G. and Mason, T.L. (1974) Ann. Rev. Biochem. 43, 51–87
Widmer, W. (1980) Science 210, 861–868.
Verrier, K. and Schatz, G. (1988) Science 241, 1307–1313.
Rothman, S.S. and J.J.L. Ho. Nonvesicular Transport, John Wiley and Sons, New York, 1985.
Liebow, C. and S.S. Rothman. Biochim. Biophys. Acta, 455: 241–253, 1976.
Rothman, S.S. and Liebow, C. (1985) Am. J. Physiol. 248, G385–392.
Grendell, J.H. and S.S. Rothman. Am. J. Physiol., 241: G67 - G73, 1981
Niederau, C., J.H. Grendell and S.S. Rothman. Biochim. Biophys. Acta. 881: 281–291, 1986.
DeLisle, R.C., Schulz, I., Tyrakowski, T., Haase, W. and Hopfer, U. (1984) Am. J. Physiol. 246, 411–418
Niederau, C., Grendell, J.H. and Rothman, S.S. (1986) Am. J. Physiol. 251, G421–429.
Ermak, T.H. and Rothman, S.S. (1981) Cell Tiss. Res. 214, 51–66.
Ermak, T.H. and S.S. Rothman. J. Ultrastruct. Res., 64: 98–113, 1978.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rothman, S.S., Goncz, K.K., Loo, B.W. (1992). Following Protein Transport with the High Resolution X-Ray Microscope. In: Michette, A.G., Morrison, G.R., Buckley, C.J. (eds) X-Ray Microscopy III. Springer Series in Optical Sciences, vol 67. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46887-5_85
Download citation
DOI: https://doi.org/10.1007/978-3-540-46887-5_85
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-13894-6
Online ISBN: 978-3-540-46887-5
eBook Packages: Springer Book Archive