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Article
Iontophoresis on Porcine and Human Gingiva
Iontophoresis is a noninvasive method that enhances drug delivery using an electric field. This method can improve drug delivery to the tissues in the oral cavity. The effects of iontophoresis on gingival drug...
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Article
Effect of Pulsed Direct Current on Iontophoretic Delivery of Pramipexole across Human Epidermal Membrane In Vitro
Pulsed direct current (PDC) iontophoresis, by allowing skin depolarization, was suggested to provide more efficient ion transport, but the extent of its enhancement effect was unclear. PDC could also offer ele...
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Article
Effect of pH on Iontophoretic Transport of Pramipexole Dihydrochloride across Human Epidermal Membrane
Drugs with higher molecular charges generally show higher flux enhancement when electromigration is the main mechanism in transdermal iontophoresis. This study evaluated the effect of decreasing the formulatio...
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Article
Evaluation of Heat Effects on Transdermal Nicotine Delivery In Vitro and In Silico Using Heat-Enhanced Transport Model Analysis
A combined experimental and computational model approach was developed to assess heat effects on drug delivery from transdermal delivery systems (TDSs) in vitro and nicotine was the model drug. A Franz diffusion ...
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Article
Modeling Temperature-Dependent Dermal Absorption and Clearance for Transdermal and Topical Drug Applications
A computational model was developed to better understand the impact of elevated skin temperatures on transdermal drug delivery and dermal clearance. A simultaneous heat and mass transport model with emphasis o...
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Article
Dissolution Chamber for Small Drug Delivery System in the Periodontal Pocket
Existing dissolution chambers have relatively large volume compared to the size of the periodontal pocket. A small volume dissolution method that simulates the physiological release environment for periodontal...
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Article
Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro
Performance of a transdermal delivery system (TDS) can be affected by exposure to elevated temperature, which can lead to unintended safety issues. This study investigated TDS and skin temperatures and their r...
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Chapter
Mechanistic Studies of Permeation Enhancers
Effective methodologies are required for the mechanistic studies of chemical permeation enhancers in topical and transdermal drug delivery. Our previous studies have employed a systematic approach (a symmetric...
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Article
Erratum to: Evaluation of Skin Permeation of β-Blockers for Topical Drug Delivery
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Chapter
Quantitative Structure–Enhancement Relationship and the Microenvironment of the Enhancer Site of Action
In the last several decades, a large number of studies on chemical permeation enhancers were performed to assist the development of topical and transdermal products. The mechanisms of chemical permeation enhan...
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Article
Ocular Delivery of pRNA Nanoparticles: Distribution and Clearance After Subconjunctival Injection
RNA nanoparticles derived from the three-way junction (3WJ) of the pRNA of bacteriophage phi29 DNA packaging motor were previously found to be thermodynamically stable. As the nanoparticles could have potentia...
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Article
Silicone Adhesive Matrix of Verapamil Hydrochloride to Provide pH-Independent Sustained Release
Providing pH-independent oral release of weakly basic drugs with conventional matrix tablets can be challenging because of the pH-dependent solubility characteristics of the drugs and the changing pH environme...
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Article
Evaluation of Skin Permeation of β-Blockers for Topical Drug Delivery
β-Blockers have recently become the main form of treatment of infantile hemangiomas. Due to the potential systemic adverse effects of β-blockers, topical skin treatment of the drugs is preferred. However, the ...
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Article
Ocular Pharmacokinetic Study Using T1 Map** and Gd-Chelate- Labeled Polymers
Recent advances in drug discovery have led to the development of a number of therapeutic macromolecules for treatment of posterior eye diseases. We aimed to investigate the clearance of macromolecular contrast...
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Article
Influence of Permeant Lipophilicity on Permeation Across Human Sclera
The objectives of this study were to determine the effects of permeant lipophilicity on permeant uptake into and transport across human sclera for transscleral delivery.
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Article
Relationship Between the Enhancement Effects of Chemical Permeation Enhancers on the Lipoidal Transport Pathway Across Human Skin Under the Symmetric and Asymmetric Conditions In Vitro
Previously, the mechanisms of action of chemical permeation enhancers (CPEs) were studied, and a quantitative structure-enhancement relationship for the lipoidal transport pathway of the stratum corneum was es...
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Article
Efficiency of Fatty Acids as Chemical Penetration Enhancers: Mechanisms and Structure Enhancement Relationship
The present study evaluated the effects of fatty acids commonly present in cosmetic and topical formulations on permeation enhancement across human epidermal membrane (HEM) lipoidal pathway when the fatty acid...
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Article
Effects of Ionic Strength on Passive and Iontophoretic Transport of Cationic Permeant Across Human Nail
Transport across the human nail under hydration can be modeled as hindered transport across aqueous pore pathways. As such, nail permselectivity to charged species can be manipulated by changing the ionic stre...
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Article
Alternating Current (AC) Iontophoretic Transport across Human Epidermal Membrane: Effects of AC Frequency and Amplitude
As a continuing effort to understand the mechanisms of alternating current (AC) transdermal iontophoresis and the iontophoretic transport pathways in the stratum corneum (SC), the objectives of the present stu...
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Article
Enhanced Transscleral Iontophoretic Transport with Ion-Exchange Membrane
Transscleral iontophoresis has been recently re-examined for drug delivery to the back of the eye. In conventional iontophoresis, due to the relatively high electromobility of the endogenous competing ions (co...
