64 Result(s)

Chapter and Conference Paper

Immunfluoreszenzmikroskopische Untersuchungen mit isolierten typspezifischen Antikörpern gegen Kollagentyp I, II und III bei Bindegewebserkrankungen

Der Organismus verfügt über mehrere verschiedene Kollagentypen (Kollagenpolymorphismus). Bisher wurden vier verschiedene Kollagentypen isoliert und charakterisiert. Kollagentyp I [α 1 (I)₂ α 2] wird von Fibroblas...

S. Gay, K. Remberger, B. C. Adelmann in Einundachtzigster Kongress (1975)

Article

Immunhistochemische Untersuchungen zur Kollagencharakterisierung in Lebercirrhosen

Using indirect immunofluorescence technique, 21 cases of hepatic cirrhosis of differing etiology were studied with type-specific antibodies to collagen type I, II, and III.

K. Remberger, S. Gay, P. P. Fietzek in Virchows Archiv A (1975)

Article

Immunhistochemical demonstration of different collagen types in the normal epiphyseal plate and in benign and malignant tumors of bone and cartilage

Several benign and malignant tumors of bone and cartilage were examined by means of type-specific collagen antibodies in connection with indirect immunofluorescence technique in order to determine wether there...

K. Remberger, S. Gay in Zeitschrift für Krebsforschung und Klinische Onkologie (1977)

Article

Presence of type III collagen in bone from a patient with osteogenesis imperfecta

Samples of bone from a patient with osteogenesis imperfecta were found to synthesize and contain type III collagen as well as type I collagen. Normal bone contains only type I collagen except in the lining cel...

P. K. Müller, K. Raisch, K. Matzen, S. Gay in European Journal of Pediatrics (1977)

Chapter and Conference Paper

Components of the Lesion and Regression

In recent years investigations have shown that the mammalian organism is endowed with genetically different kinds of collagen. So far the following kinds of different collagen molecules have been isolated and ...

S. Gay, L. Balleisen in Atherosclerosis — is it reversible? (1978)

Article

Autoantibodies to extracellular collagen matrix components in epidermolysis bullosa and other bullous diseases

In order to determine whether autoantibodies are present in sera from normal individuals and/or patients with selected bullous disorders, a highly sensitive solid-phase radioimmune assay was established using ...

S. Gay, J. -D. Fine, J. S. Storer in Archives of Dermatological Research (1988)

Chapter

The Collagenous Hemopoietic Microenvironment

The collagens of the connective tissues serve to support a variety of tissue architectures throughout the body.¹ The various structural elements of the collagens preserve the physical and functional integrity of ...

Renate E. Gay, C. W. Prince, K. S. Zuckerman… in Handbook of the Hemopoietic Microenvironme… (1989)

Article

Cellular basis and oncogene expression of rheumatoid joint destruction

A new animal model for human rheumatoid arthritis is described, and the unsolved questions regarding the mechanism of primary joint destruction are discussed. Following an analysis of the types of cells and an...

S. Gay, R. E. Gay in Rheumatology International (1989)

Chapter and Conference Paper

Oncogenes and Retroviruses in Rheumatoid Arthritis

Rheumatoid arthritis is a chronic systemic disorder of currently still unknown etiology. Its most serious and debilitating consequences are derived from the destruction of affected joints. An exceedingly large...

G. Stransky, R. E. Gay, A. Trabandt, W. K. Aicher, S. R. Barnum… in Rheumatoid Arthritis (1992)

Article

Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts

In view of the important role of interstitial collagenase in the pathogenesis of rheumatoid arthritis (RA), we studied the expression of fibroblast-type collagenase in rheumatoid synovium and searched for its ...

A. Trabandt, W. K. Aicher, R. E. Gay, V. P. Sukhatme… in Rheumatology International (1992)

Article

Scanning electron microscopic evaluation of the arthritis in MRL/lpr mice

The articular surfaces of disarticulated knee joints from MRL/lpr and MRL/n mice, aged 4–33 weeks were examined by light microscopy (LM) and scanning electron microscopy (SEM). Light microscopy did not reliabl...

F. X. O'Sullivan, W. J. Koopman, S. Gay in Rheumatology International (1992)

Article

Hemmung der Knorpeldestruktion durch retroviralen Gentransfer: Erkenntnisse aus dem SCID Maus-Modell

U. Müller-Ladner, S. Gay in Zeitschrift für Rheumatologie (1998)

Article

Persistent high serum levels of cartilage oligomeric matrix protein in a subgroup of patients with traumatic knee injury

The objective was to assess whether changes of cartilage oligomeric matrix protein (COMP) serum levels can predict the development of osteoarthritis following traumatic knee injury. Sera and synovial fluids w...

S. A. M. Kühne, M. Neidhart, M. P. Everson, H. Häntzschel… in Rheumatology International (1998)

Article

Expression of RANTES in biopsies of skin and upper gastrointestinal tract from patients with systemic sclerosis

Inflammatory infiltrates and upregulated collagen production are hallmarks of systemic sclerosis (SSc). There are indications that chemokines are involved in accumulation of inflammatory and matrix-synthesizi...

O. Distler, B. Rinkes, U. Hohenleutner, J. Schölmerich… in Rheumatology International (1999)

Article

"Inverse wrap": an improved implantation technique for virus-transduced synovial fibroblasts in the SCID mouse model for rheumatoid arthritis

The SCID mouse model for rheumatoid arthritis (RA) is an established and reliable approach to examining the distinct mechanisms operative in RA synovium, and evaluating novel gene therapy strategies. However,...

M. Judex, E. Neumann, M. Fleck, T. Pap, J. D. Mountz, R. E. Gay… in Modern Rheumatology (2001)

Article

Die Rheumatoide Arthritis: Neuentwicklungen in der Pathogenese unter besonderer Berücksichtigung der synovialen Fibroblasten

Die Pathophysiologie der rheumatoiden Arthritis (RA) ist durch eine synoviale Hyperplasie, pathologische Immunphänomene und eine progressive Gelenkzerstörung gekennzeichnet. Eine Vielzahl verschiedener Zellty...

C. A. Seemayer, O. Distler, S. Kuchen, U. Müller-Ladner… in Zeitschrift für Rheumatologie (2001)