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Article
PD-L1 expression, BRAF and TERT mutation in a cohort of aggressive thyroid cancers: case series from a single-centre experience
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Article
Open AccessImpact of microscopic extrathyroidal extension on differentiated thyroid cancer post-surgical risk of recurrence: a retrospective analysis
In the last edition of the American Joint Committee on Cancer (AJCC) staging system, differentiated thyroid cancers (DTC) showing microscopic extrathyroidal extension (mETE) are considered comparable to intrat...
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Article
Evaluation of adequacy of levo-thyroxine dosage in patients with differentiated thyroid carcinoma: correlation between morning and afternoon TSH determination
The aim of this study was to judge the reliability of evaluating thyroid-stimulating hormone (TSH) and free thyroxine (f-T4) in the morning and afternoon in differentiated thyroid carcinoma (DTC) patients.
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Article
A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels
Long non-coding RNAs (lncRNAs) can regulate the transcript levels of genes in the same genomic region. These locally acting lncRNAs have been found deregulated in human disease and some have been shown to harb...
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Article
Epigenetische Modifikationen bei Autoimmunerkrankungen
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Epigenetik bei entzündlichen Systemerkrankungen
In den letzten Jahren wurden neben genetischen Studien immer mehr Analysen von Veränderungen im epigenetischen Code durchgeführt. Epigenetische Mechanismen bestimmen, welche Gene in welcher Zelle transkribiert...
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Article
DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts
In the search for specific genes regulated by DNA methylation in rheumatoid arthritis (RA), we investigated the expression of CXCL12 in synovial fibroblasts (SFs) and the methylation status of its promoter and...
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Article
Epigenetik in der Rheumatologie
Die Erbsubstanz aller Lebewesen besteht aus DNA („desoxyribonucleic acid“). Jede Zelle unseres Körpers enthält die gleiche genetische Ausstattung. In embryonalen Stammzellen ist eine gleichbleibende Anzahl Gen...
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Article
Sklerodermie
Die Sklerodermie (Synonyme: systemische Sklerose, systemische Sklerodermie) ist eine Systemerkrankung, die neben der Haut auch innere Organe wie die Lunge, den Gastrointestinaltrakt, die Niere und das Herz bef...
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Article
Systemische Sklerose
Die systemische Sklerose (SSc) ist eine Multisystemfibrose mit weltweitem Vorkommen und hoher Morbidität und Mortalität. Charakteristika der Erkrankung sind ausgedehnte Vaskulopathie, Entzündung, Autoimmunität...
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Article
Laminin-modulierte Entzündungsreaktionen in synovialen Fibroblasten von Rheumapatienten
Die hohe Expression von Matrix-Metalloproteinasen (MMP) ist bei rheumatoider Arthritis an der Knorpeldestruktion beteiligt. Wir zeigen einen neuen Weg der entzündlichen Aktivierung von synovialen Fibroblasten,...
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Investigation of the role of the p38 MAPK α and δ isoforms in nonresponse to tumour necrosis factor blockade in the synovium of rheumatoid arthritis patients
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Article
Molekulare Mechanismen
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Article
Angiogenese – therapeutische Interventionsmöglichkeiten bei rheumatischen Erkrankungen
Im Gegensatz zur Vaskulogenese bedeutet Angiogenese die Formation neuer Blutgefäße aus bereits bestehenden Gefäßen. Dieser vielschrittige Prozess tritt beim Erwachsenen physiologisch nur während des Reprodukti...
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Chapter
Forecasting Flash Floods with an Operational Model
The flash flood forecasting model ALHTAÏR (“Alarme Hydrologique Territoriale Automatisée par Indicateur de Risque”) has been developed during the last five years by the flood-warning service of the Gard Region...
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Article
The release of microparticles by apoptotic cells and their effects on macrophages
Microparticles are small membrane vesicles released from the cell membrane by exogenous budding. To elucidate the interactions of microparticles with macrophages, the effect of microparticles released from Jur...
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Article
Regulated and constitutive expression of anti-inflammatory cytokines by nontransforming herpesvirus saimiri vectors
Herpesviral saimiri-(HVS) mediated expression of bovine growth hormone was one of the first applications of an episomal viral vector for gene therapy. Meanwhile, the long-term persistence of HVS vectors has be...
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Article
Microparticles from inflammatory cells are strong inducers of matrix metalloproteinases and inflammatory cytokines in synovial fibroblasts
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Toll-like receptor expression in synovial fibroblasts and normal skin fibroblasts and induction of matrix metallo-proteinase expression by various Toll-like receptor ligands
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The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis