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  1. Article

    Open Access

    Serum metabolites as biomarkers in systemic sclerosis-associated interstitial lung disease

    Systemic sclerosis (SSc) is a severe multi-organ disease with interstitial lung disease (ILD) being the major cause of death. While targeted therapies are emerging, biomarkers for sub-stratifying patients base...

    C. Meier, K. Freiburghaus, C. Bovet, J. Schniering, Y. Allanore… in Scientific Reports (2020)

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  2. Article

    Open Access

    ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis—a EUSTAR analysis

    To investigate the effect of ACE inhibitors (ACEi) on the incidence of scleroderma renal crisis (SRC) when given prior to SRC in the prospectively collected cohort from the European Scleroderma Trial and Resea...

    Lukas Bütikofer, Pierre A. Varisco, O. Distler… in Arthritis Research & Therapy (2020)

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  3. No Access

    Article

    Use of vasoactive/vasodilating drugs for systemic sclerosis (SSc)-related digital ulcers (DUs) in expert tertiary centres: results from the analysis of the observational real-life DeSScipher study

    DeSScipher is the first European multicentre study on management of systemic sclerosis (SSc), and its observational trial 1 (OT1) evaluated the efficacy of different drugs for digital ulcer (DU) prevention and...

    Jelena Blagojevic, G. Abignano, J. Avouac, L. Cometi, M. Frerix… in Clinical Rheumatology (2020)

  4. No Access

    Article

    Systemische Sklerose – klinisches Bild, Diagnostik und Therapie

    Die systemische Sklerose ist eine seltene rheumatische Erkrankung, die durch Haut- und Organfibrose, vaskuläre Veränderungen und das Auftreten spezifischer Autoantikörper charakterisiert ist. Sie zeigt eine ho...

    Dr. med. M. O. Becker, O. Distler, B. Maurer in Der Hautarzt (2019)

  5. No Access

    Article

    Systemische Sklerose – klinisches Bild, Diagnostik und Therapie

    Die systemische Sklerose ist eine seltene rheumatische Erkrankung, die durch Haut- und Organfibrose, vaskuläre Veränderungen und das Auftreten spezifischer Autoantikörper charakterisiert ist. Sie zeigt eine ho...

    Dr. med. M. O. Becker, O. Distler, B. Maurer in Zeitschrift für Rheumatologie (2019)

  6. No Access

    Article

    Formen der Vaskulitis

    Die Vaskulitiden sind (zumeist seltene) entzündliche Gefäßerkrankungen mit sehr heterogenem klinischem Erscheinungsbild. Sie können akut auftreten und lebensbedrohlich sein und erfordern häufig eine interdiszi...

    Dr. M. O. Becker, B. Maurer, O. Distler in Gefässchirurgie (2019)

  7. No Access

    Article

    Therapiestrategien bei systemischen Vaskulitiden

    Die Therapie der Vaskulitiden umfasst heutzutage die gesamte Breite der konventionellen immunsuppressiven Medikamente sowie einzelne Biologika (insbesondere Rituximab). Im Einzelfall wird die medikamentöse The...

    Dr. M. O. Becker, B. Maurer, O. Distler in Gefässchirurgie (2019)

  8. Article

    Open Access

    Classification, categorization and essential items for digital ulcer evaluation in systemic sclerosis: a DeSScipher/European Scleroderma Trials and Research group (EUSTAR) survey

    A consensus on digital ulcer (DU) definition in systemic sclerosis (SSc) has been recently reached (Suliman et al., J Scleroderma Relat Disord 2:115-20, 2017), while for their evaluation, classification and ca...

    J. Blagojevic, S. Bellando-Randone, G. Abignano, J. Avouac… in Arthritis Research & Therapy (2019)

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  9. No Access

    Article

    Gemeinsame deutschsprachige Nomenklatur für die systemische Sklerose

    Große Datenbanken und darauf aufbauende Projekte haben im letzten Jahrzehnt ein sehr viel besseres Verständnis des Krankheitsbildes systemische Sklerose (SSc) gebracht. Die Serologie hat sich weiterentwickelt,...

    Prof. Dr. M. Aringer, U. Müller-Ladner, H. Burkhardt… in Zeitschrift für Rheumatologie (2015)

  10. No Access

    Article

    Profile of gastrointestinal involvement in patients with systemic sclerosis

    Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease. Of the numerous organ manifestations, involvement of the upper and lower gastrointestinal tract (GIT) appears to be the most frequent...

    T. Schmeiser, P. Saar, D. **, M. Noethe, A. Müller… in Rheumatology International (2012)

  11. No Access

    Article

    The release of microparticles by apoptotic cells and their effects on macrophages

    Microparticles are small membrane vesicles released from the cell membrane by exogenous budding. To elucidate the interactions of microparticles with macrophages, the effect of microparticles released from Jur...

    J. H. W. Distler, L. C. Huber, A. J. Hueber, C. F. Reich III, S. Gay… in Apoptosis (2005)

  12. Article

    Microparticles from inflammatory cells are strong inducers of matrix metalloproteinases and inflammatory cytokines in synovial fibroblasts

    JHW Distler, A Jüngel, LC Huber, A Seemayer, RE Gay… in Arthritis Research & Therapy (2005)

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  13. Article

    The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis

    M Kurowska-Stolarska, J Distler, W Rudnicka, E Neumann… in Arthritis Research & Therapy (2005)

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  14. Article

    In systemic sclerosis, levels of tissue kallikrein are related to microvascular changes assayed by videocapillaroscopy and immunohistochemistry

    A Del Rosso, AF Milia, LI Manneschi, O Distler, S Guiducci… in Arthritis Research & Therapy (2005)

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  15. No Access

    Article

    Vaskuläre Veränderungen in der Pathogenese der systemischen Sklerose

    Die systemische Sklerose (SSc, Sklerodermie) ist eine Erkrankung des Bindegewebes, die durch eine Akkumulation von Proteinen der Extrazellularmatrix in der Haut und in inneren Organen gekennzeichnet ist. Weite...

    J. H. W. Distler, J. R. Kalden, S. Gray, O. Distler in Zeitschrift für Rheumatologie (2004)

  16. Article

    Novel tools for molecular analysis in synovium

    U Mueller-Ladner, E Neumann, I Tarner, J Grifka, O Distler, A Wunder… in Arthritis Res Ther (2003)

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  17. Article

    IL-15 and its role in rheumatoid arthritis

    M Kurowska-Stolarska, O Distler, W Rudnicka, J Distler, RE Gay… in Arthritis Res Ther (2003)

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  18. Article

    IL-21R mRNA is overexpressed in systemic sclerosis and contributes to the epidermal/dermal cross-talk

    O Distler, J Distler, A Hirth, U Müller-Ladner, M Matucci-Cerinic… in Arthritis Res Ther (2003)

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  19. No Access

    Article

    Chemokines and chemokine receptors in the pathogenesis of systemic sclerosis

     Activation of the immune system and increased synthesis of extracellular matrix proteins by fibroblasts are hallmarks in the pathogenesis of systemic sclerosis (SSc). The mechanisms that initiate the accumula...

    O. Distler, J. Distler, O. Kowal-Bielecka, R. E. Gay… in Modern Rheumatology (2002)

  20. Article

    Efficacy of retroviral gene transfer into synovial fibroblasts is reduced by co-transduction with adenoviral vectors

    U Müller-Ladner, O Distler, S Gay, E Neumann, M Judex… in Arthritis Research & Therapy (2002)

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