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  1. No Access

    Chapter and Conference Paper

    Results of a Phase II Rheumatoid Arthritis Clinical Trial Using T-Cell Receptor Peptides

    Restricted T-cell receptor gene use has been found in animal models of autoimmune disease. This observation has resulted in the successful use of T-cell receptor peptide therapy in animal studies. Initial phas...

    S. W. Brostoff, D. J. Carlo, J. P. Diveley, E. E. Morgan… in Advances in Osteoarthritis (1999)

  2. No Access

    Article

    Occurrence of deficient galactosylation of serum IgG prior to the onset of rheumatoid arthritis

    Previous reports have shown that deficient galactosylation of serum IgG occurs in patients with rheumatoid arthritis (RA) and other autoimmune disorders. In this study, we investigated the relationship between...

    M. Tomana, R. E. Schrohenloher, P. H. Bennett, A. del Puente… in Rheumatology International (1994)

  3. No Access

    Article

    Abnormal galactosylation of serum IgG in patients with systemic lupus erythematosus and members of families with high frequency of autoimmune diseases

    Gas chromatographic carbohydrate analyses of IgG from 30 patients with idiopathic systemic lupus erythematosus (SLE) revealed lower content of galactose when compared to that in 36 controls of similar ages (me...

    M. Tomana, R. E. Schrohenloher, J. D. Reveille, F. C. Arnett… in Rheumatology International (1992)

  4. No Access

    Article

    Scanning electron microscopic evaluation of the arthritis in MRL/lpr mice

    The articular surfaces of disarticulated knee joints from MRL/lpr and MRL/n mice, aged 4–33 weeks were examined by light microscopy (LM) and scanning electron microscopy (SEM). Light microscopy did not reliabl...

    F. X. O'Sullivan, W. J. Koopman, S. Gay in Rheumatology International (1992)

  5. No Access

    Article

    Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin

    Female MRL/lpr mice were treated with I.P. doses of methotrexate (MTX) and 10-deazaaminopterin (DAAM) in the range of 1 to 100 mg/kg body weight/week, in two equally divided doses. Treatment began at 7 weeks o...

    J. E. Baggott, S. L. Morgan, L. E. Freeberg, B. B. Hudson… in Agents and Actions (1992)

  6. No Access

    Article

    Occurrence of a rheumatoid factor cross-reactive kappa light-chain idiotope in rheumatoid arthritis families

    The occurrence of IgM rheumatoid factor (RF) and RF-associatedκ-III light-chain idiotope identified by monoclonal antibody 6B6.6 in the serum from 22 patients with rheumatoid arthritis (RA) and 68 relatives witho...

    R. E. Schrohenloher, G. S. Alarcón, W. J. Koopman in Rheumatology International (1990)

  7. No Access

    Article

    Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation

    Methotrexate (MTX) is an anti-folate drug used in cancer chemotherapy because of its anti-proliferative effects. However, it is unclear whether the anti-proliferative effects of MTX contribute to the efficacy ...

    R. J. Hine, M. P. Everson, J. M. Hardin, S. L. Morgan… in Rheumatology International (1990)

  8. No Access

    Article

    Enhanced in vitro IgM rheumatoid factor synthesis in seropositive rheumatoid arthritis families

    We studied the patterns of in vitro IgM RF production by peripheral blood mononuclear leukocytes (MNL) in first- and second-degree relatives and non-blood relatives of 14 RA patients. In all these included 25 ...

    G. S. Alarcón, B. O. Barger, R. C. P. Go, R. T. Acton… in Rheumatology International (1987)

  9. No Access

    Article

    HLA antigens and gold toxicity in American blacks with rheumatoid arthritis

    An increase in the frequency of DR3 in rheumatoid arthritis (RA) patients exhibiting toxic reactions to gold salt (GS) therapy has been observed in several studies of Caucasoid patients. Likewise, the associat...

    G. S. Alarcón, B. O. Barger, R. T. Acton, W. J. Koopman in Rheumatology International (1986)

  10. No Access

    Article

    In vitro synthesis of IgM and IgM rheumatoid factor in seronegative arthritides

    In vitro patterns of IgM and IgM rheumatoid factor (RF) synthesis exhibited by peripheral blood B cells (MNL) obtained from healthy individuals as well as patients with seropositive and seronegative rheumatoid...

    G. S. Alarcón, W. J. Koopman, R. E. Schrohenloher in Rheumatology International (1984)

  11. No Access

    Article

    Buffer electrofocusing of Interleukin I

    R. L. Prestidge, W. J. Koopman, J. C. Bennett, M. T. W. Hearn in Bioscience Reports (1982)