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  1. No Access

    Article

    Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

    T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. The median...

    E I Andersson, S Pützer, B Yadav, O Dufva, S Khan, L He, L Sellner, A Schrader… in Leukemia (2018)

  2. Article

    Open Access

    Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

    Somatic mutations contribute to tumorigenesis. Although these mutations occur in all proliferating cells, their accumulation under non-malignant conditions, such as in autoimmune disorders, has not been invest...

    P. Savola, T. Kelkka, H. L. Rajala, A. Kuuliala, K. Kuuliala… in Nature Communications (2017)

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  3. No Access

    Article

    Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

    In our individualized systems medicine program, personalized treatment options are identified and administered to chemorefractory acute myeloid leukemia (AML) patients based on exome sequencing and ex vivo drug s...

    P N Ojamies, M Kontro, H Edgren, P Ellonen, S Lagström, H Almusa, T Miettinen… in Leukemia (2017)

  4. No Access

    Article

    Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia

    E Andersson, H Kuusanmäki, S Bortoluzzi, S Lagström, A Parsons, H Rajala… in Leukemia (2016)

  5. No Access

    Article

    Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

    M Kontro, H Kuusanmäki, S Eldfors, T Burmeister, E I Andersson, Ø Bruserud… in Leukemia (2014)