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Article
Open AccessProstate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in te...
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Article
Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. The median...
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Article
Open AccessSomatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis
Somatic mutations contribute to tumorigenesis. Although these mutations occur in all proliferating cells, their accumulation under non-malignant conditions, such as in autoimmune disorders, has not been invest...
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Article
Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia
In our individualized systems medicine program, personalized treatment options are identified and administered to chemorefractory acute myeloid leukemia (AML) patients based on exome sequencing and ex vivo drug s...
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Article
Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia
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Article
Open AccessNovel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation
T-cell large granular lymphocytic (T-LGL) leukemia is a clonal disease characterized by the expansion of mature CD3+CD8+ cytotoxic T cells. It is often associated with autoimmune disorders and immune-mediated ...
