20 Result(s)

Article

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

M Kontro, H Kuusanmäki, S Eldfors, T Burmeister, E I Andersson, Ø Bruserud… in Leukemia (2014)

Article

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia

Although TP53 mutations are rare in acute myeloid leukemia (AML), wild type p53 function is habitually annulled through overexpression of MDM2 or through various mechanisms including epigenetic silencing by histo...

E McCormack, I Haaland, G Venås, R B Forthun, S Huseby, G Gausdal, S Knappskog… in Leukemia (2012)

Article

The surface molecule signature of primary human acute myeloid leukemia (AML) cells is highly associated with NPM1 mutation status

G Tsykunova, H Reikvam, R Hovland, Ø Bruserud in Leukemia (2012)

Article

Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia

The wild-type tumor-suppressor gene TP53 encodes several isoforms of the p53 protein. However, while the role of p53 in controlling normal cell cycle progression and tumor suppression is well established, the cli...

N Ånensen, S M Hjelle, W Van Belle, I Haaland, E Silden, J-C Bourdon, R Hovland… in Oncogene (2012)

Article

Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels

The balance between proangiogenic Angiopoietin-1 (Ang-1) and the antagonistic Ang-2 is important both for leukemogenesis and chemosensitivity in human acute myelogenous leukemia (AML). We examined the release ...

K J Hatfield, R Hovland, A M Øyan, K H Kalland, A Ryningen, B T Gjertsen… in Leukemia (2008)

Article

Acute myelogenous leukemia in a patient with Li–Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report

N Ånensen, J Skavland, C Stapnes, A Ryningen, A-L Børresen-Dale, B T Gjertsen… in Leukemia (2006)

Article

Animal models of acute myelogenous leukaemia – development, application and future perspectives

From the early inception of the transplant models through to contemporary genetic and xenograft models, evolution of murine leukaemic model systems have been critical to our general comprehension and treatment...

E Mc Cormack, Ø Bruserud, B T Gjertsen in Leukemia (2005)

Article

Antiproliferative effects of a non-β-oxidizable fatty acid, tetradecylthioacetic acid, in native human acute myelogenous leukemia blast cultures

The lipid metabolism is important in the regulation of cell proliferation. We have examined effects of a fatty acid analogue, tetradecylthioacetic acid (TTA), on the functional phenotype of native, human AML c...

KJ Tronstad, Ø Bruserud, K Berge, RK Berge in Leukemia (2002)

Article

Flow cytometric measurement of apoptosis and necrosis in cryopreserved PBPC concentrates from patients with malignant diseases

The number of viable precursor cells actually reinfused into patients after high-dose chemotherapy is one of the most clinically important variables determining graft success or failure. A modified, previously...

JF Abrahamsen, AM Bakken, Ø Bruserud, BT Gjertsen in Bone Marrow Transplantation (2002)

Article

Acute myelogenous leukemia blasts as accessory cells during T lymphocyte activation: possible implications for future therapeutic strategies

Both clinical and experimental evidence indicate that T lymphocytes can mediate antileukemic effects in acute myelogenous leukemia (AML). These antileukemic effects can be either nonspecific cytotoxicity (kill...

Ø Bruserud in Leukemia (1999)

Article

Response to K Shinjo et al

Ø Bruserud, B Foss in Leukemia (1998)

Article

Serum thrombopoietin levels in acute leukemia patients with chemotherapy-induced cytopenia – inverse correlation between serum levels and platelet counts

Ø Bruserud, B Foss in Leukemia (1998)

Article

Comment from Ø Bruseard

Ø Bruserud in Leukemia (1997)

Article

Serum levels of soluble ICAM-1 in acute leukemia patients with chemotherapy-induced neutropenia

Ø Bruserud in Leukemia (1997)

Article

Human T lymphocyte activation in the presence of acute myelogenous leukaemia blasts; studies of normal polyclonal T cells and T lymphocyte clones derived early after allogeneic bone marrow transplantation

 T cell clones (CD4⁺CD8^–TCRαβ⁺γδ^–) derived from bone marrow transplant recipients were stimulated with phytohaemagglutinin (PHA) +interleukin-2 (IL-2) in the presence of irradiated (50 Gy) peripheral blood mononu...

Ø. Bruserud, Graham Pawelec in Cancer Immunology, Immunotherapy (1996)

Chapter

The Role of Human Class II Molecules in Activation of T4 Lymphocytes

While B lymphocytes can bind antigen directly, T lymphocytes recognize antigen only when presented together with major histocompatibility complex (MHC)-en-coded class I or II molecules in the membrane of antig...

E. Qvigstad, Ø. Bruserud, E. Thorsby in HLA Class II Antigens (1986)