14 Result(s)

Article

Localized fine-tuning and clinical evaluation of deep-learning based auto-segmentation (DLAS) model for clinical target volume (CTV) and organs-at-risk (OAR) in rectal cancer radiotherapy

Various deep learning auto-segmentation (DLAS) models have been proposed, some of which have been commercialized. However, the issue of performance degradation is notable when pretrained models are deployed in...

Jianhao Geng, **n Sui, Rongxu Du, Jialin Feng, Ruoxi Wang… in Radiation Oncology (2024)

Article

Pyrotinib and trastuzumab plus palbociclib and fulvestrant in HR+/HER2+ breast cancer patients with brain metastasis

Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients are at a high risk of develo** metastases in the brain. However, research focusing on treatment strategies for hormonal r...

Dongshao Chen, Fei Xu, Yongkui Lu, Wen **a, Caiwen Du, Dun **ong… in npj Breast Cancer (2024)

Article

Genetic analysis of oligo-recurrence breast cancer: correlation with clinical outcomes

We aimed to identify the relationship between the genomic characteristics and clinical outcomes of oligo-metastatic breast cancer.

Kuikui Jiang, Danyang Zhou, Fei Xu, Wen **a, Qiufan Zheng, Qianyi Lu… in BMC Cancer (2023)

Article

The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms

N6-methyladenosine(m⁶A) is one of the most abundant modifications of mammalian cellular RNAs. m⁶A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, transl...

Zhihua Lv, Ruoxi Ran, Yuting Yang, Meixian **ang, Hanwen Su… in Discover Oncology (2023)

Article

The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer

This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC pa...

Danyang Zhou, Mei Li, Mohamed Hussein Yasin, Qianyi Lu, Jia Fu… in npj Breast Cancer (2023)

Article

The diagnostic and prognostic implications of PRKRA expression in HBV-related hepatocellular carcinoma

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) accounts for more than half of total HCC patients in develo** countries. Currently, HBV-related HCC diagnosis and prognosis still lack specific ...

Yi-Min Hu, Ruoxi Ran, Chaoqi Yang, Song-Mei Liu in Infectious Agents and Cancer (2022)

Article

Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-mo...

Ruoxi **e, Zijun Wu, Fanxin Zeng, Huawei Cai… in Signal Transduction and Targeted Therapy (2021)

Article

The STING1 network regulates autophagy and cell death

Cell death and immune response are at the core of life. In past decades, the endoplasmic reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a fundamental role in the production of...

Ruoxi Zhang, Rui Kang, Daolin Tang in Signal Transduction and Targeted Therapy (2021)

Article

CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4

Ka** Lee, Qiufan Zheng, Qianyi Lu, Fei Xu… in Signal Transduction and Targeted Therapy (2021)

Article

Comorbidity in lung cancer patients and its association with hospital readmission and fatality in China

Comorbidity has been established as one of the important predictors of poor prognosis in lung cancer. In this study, we analyzed the prevalence of main comorbidities and its association with hospital readmissi...

Dawei Zhu, Ruoxi Ding, Yong Ma, Zhishui Chen, Xuefeng Shi, ** He in BMC Cancer (2021)

Article

Comorbidity in lung cancer patients and its association with medical service cost and treatment choice in China

It is evident that comorbidity exacerbate the complexity of the management of lung cancer, however, limited research has been conducted to investigate the impact of comorbidity on health service utilization an...

Ruoxi Ding, Dawei Zhu, ** He, Yong Ma, Zhishui Chen, Xuefeng Shi in BMC Cancer (2020)

Article

The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment

The prognosis for esophageal squamous cell carcinoma (ESCC) patients with lymph node metastasis (LNM) is still dismal. Elucidation of the LNM associated genomic alteration and underlying molecular mechanisms m...

Weimin Zhang, Ruoxi Hong, Lin Li, Yan Wang, Peina Du, Yunwei Ou… in Molecular Cancer (2018)

Article

Erratum to: 53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells

Ruoxi Hong, Fei Ma, Weimin Zhang, **ying Yu, Qing Li, Yang Luo, Changjun Zhu… in BMC Cancer (2016)

Article

53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells

Mutations in DNA damage response factors BRCA1 and BRCA2 confer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors in breast and ovarian cancers. BRCA1/BRCA2-defective tumors can exhibit resistance t...

Ruoxi Hong, Fei Ma, Weimin Zhang, **ying Yu, Qing Li, Yang Luo, Changjun Zhu… in BMC Cancer (2016)