39 Result(s)

Article

Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth

Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as the disease only becomes symptomatic at an advanced stage. Growing evidence suggests that histone deacetylases (HDACs),...

Namin Duan, **aohui Hu, Huiran Qiu, Rui Zhou, Yuru Li, Wenxia Lu… in Cell Death & Disease (2023)

Article

RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury

Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention ...

Pei-Yao Liu, Chih-Yuan Chen, Yu-Lung Lin, Chien-Ming Lin… in Cell Death & Disease (2023)

Article

Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy

The transcription factor hypoxia-inducible factor-1α (HIF-1α), as a master regulator of adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD), and C-terminal (...

Zuo-Lin Li, Lin Ding, Rui-**a Ma, Yue Zhang, Yi-Lin Zhang… in Cell Death & Disease (2023)

Article

Author Correction: A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

Li-Heng Che, **g-Wen Liu, Jian-** Huo, Rong Luo, Rui-Min Xu, Cai He… in Cell Discovery (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)

Article

Retraction Note: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer

Hong-En Yu, Feng Wang, Fang Yu, Zhao-Lei Zeng, Yun Wang, Yun-**n Lu… in Cell Death & Disease (2023)

Article

Cancer-derived exosomal miR-197-3p confers angiogenesis via targeting TIMP2/3 in lung adenocarcinoma metastasis

Cancer-derived exosomal miRNAs are implicated in tumorigenesis and development of lung adenocarcinoma (LUAD). The objective of this study is to unravel the biological function of exosomal miR-197-3p in LUAD me...

Rui-Min Chang, Yao Fu, Jun Zeng, **ao-Yan Zhu, Yang Gao in Cell Death & Disease (2022)

Article

Retraction Note: MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2

Wen-Fei Wei, Chen-Fei Zhou, **ang-Guang Wu, Li-Na He, Lan-Fang Wu… in Cell Death & Disease (2022)

Article

E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway

Breast cancer (BC) is the most common malignant tumor in women worldwide. Metastasis is the main cause of BC-related death. The specific mechanism underlying BC metastasis remains obscure. Recently, PRSS22 was...

Lin Song, Hui Li, Ran-Ran Ma, Sen Liu, Guo-Hao Zhang, **ang-Yu Guo… in Cell Death & Disease (2022)

Article

Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice

Genetic studies have proved the involvement of Tuberous sclerosis complex subunit 2 (Tsc2) in aortic aneurysm. However, the exact role of macrophage Tsc2 in the vascular system remains unclear. Here, we examin...

Xue Liu, Yan Liu, Rui-xue Yang, **ang-jiu Ding, Er-shun Liang in Cell Death & Disease (2022)

Article

Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury

Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorde...

**-**a Hu, Wei-**g Ma, Li-Ying He, Cong-Hui Zhang, Cheng Zhang… in Cell Death & Disease (2022)

Article

Correction: Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

**ao-**g Chen, Yuan-Run Deng, Zi-Ci Wang, Wen-Fei Wei… in Cell Death & Disease (2022)

Article

Identification of oligosaccharyltransferase as a host target for inhibition of SARS-CoV-2 and its variants

Yi-Jiao Huang, Hui Zhao, Xun Huang, Yong-Qiang Deng, **ao-Feng Li… in Cell Discovery (2021)

Article

A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC) patients. How to improve therapeutic options for patients with metastatic CRC is the core question for CRC treatment. Howe...

Li-Heng Che, **g-Wen Liu, Jian-** Huo, Rong Luo, Rui-Ming Xu, Cai He… in Cell Discovery (2021)

Article

Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism

Although high-fat diet (HFD) has been implicated in the development of colorectal cancer (CRC), the critical signaling molecule that mediates the cancer growth is not well-defined. Identifying the master regul...

**an**g Hu, Sarwat Fatima, Minting Chen, Keyang Xu, Chunhua Huang… in Cell Death & Disease (2021)

Article

SARS-CoV-2 infection in the mouse olfactory system

SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in humans, and olfactory dysfunction is one of the most predictive and common symptoms in COVID-19 patients. However, the underlying mecha...

Qing Ye, Jia Zhou, Qi He, Rui-Ting Li, Guan Yang, Yao Zhang, Shu-Jia Wu… in Cell Discovery (2021)

Article

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...

Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen… in Cell Death & Disease (2021)

Article

High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner

Epidemiology studies indicate that consumption of high-fat diet (HFD) is directly associated with the development of colorectal cancer (CRC). However, the exact component in HFD and the mechanism underlying it...

Sarwat Fatima, **an**g Hu, Chunhua Huang, Weixiong Zhang, **g Cai… in Cell Death & Disease (2019)

Article

Signal transducer and activator of transcription-3 drives the high-fat diet-associated prostate cancer growth

Prostate cancer (PCa) is the second leading cause of cancer death in men. PCa progression can be associated with obesity. Signal transducer and activator of transcription-3 (STAT3) plays a crucial role in PCa ...

Hiu Yee Kwan, Bin Liu, Chunhua Huang, Sarwat Fatima, Tao Su… in Cell Death & Disease (2019)

Article

Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

The accumulation of tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is associated with malignant progression in cancer. However, the mechanisms by which the hypoxic TME facili...

**ao-**g Chen, Yuan-Run Deng, Zi-Ci Wang, Wen-Fei Wei… in Cell Death & Disease (2019)