30 Result(s)

Article

Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth

Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as the disease only becomes symptomatic at an advanced stage. Growing evidence suggests that histone deacetylases (HDACs),...

Namin Duan, **aohui Hu, Huiran Qiu, Rui Zhou, Yuru Li, Wenxia Lu… in Cell Death & Disease (2023)

Article

RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury

Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention ...

Pei-Yao Liu, Chih-Yuan Chen, Yu-Lung Lin, Chien-Ming Lin… in Cell Death & Disease (2023)

Article

Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy

The transcription factor hypoxia-inducible factor-1α (HIF-1α), as a master regulator of adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD), and C-terminal (...

Zuo-Lin Li, Lin Ding, Rui-**a Ma, Yue Zhang, Yi-Lin Zhang… in Cell Death & Disease (2023)

Article

Retraction Note: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer

Hong-En Yu, Feng Wang, Fang Yu, Zhao-Lei Zeng, Yun Wang, Yun-**n Lu… in Cell Death & Disease (2023)

Article

Cancer-derived exosomal miR-197-3p confers angiogenesis via targeting TIMP2/3 in lung adenocarcinoma metastasis

Cancer-derived exosomal miRNAs are implicated in tumorigenesis and development of lung adenocarcinoma (LUAD). The objective of this study is to unravel the biological function of exosomal miR-197-3p in LUAD me...

Rui-Min Chang, Yao Fu, Jun Zeng, **ao-Yan Zhu, Yang Gao in Cell Death & Disease (2022)

Article

Retraction Note: MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2

Wen-Fei Wei, Chen-Fei Zhou, **ang-Guang Wu, Li-Na He, Lan-Fang Wu… in Cell Death & Disease (2022)

Article

E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway

Breast cancer (BC) is the most common malignant tumor in women worldwide. Metastasis is the main cause of BC-related death. The specific mechanism underlying BC metastasis remains obscure. Recently, PRSS22 was...

Lin Song, Hui Li, Ran-Ran Ma, Sen Liu, Guo-Hao Zhang, **ang-Yu Guo… in Cell Death & Disease (2022)

Article

Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice

Genetic studies have proved the involvement of Tuberous sclerosis complex subunit 2 (Tsc2) in aortic aneurysm. However, the exact role of macrophage Tsc2 in the vascular system remains unclear. Here, we examin...

Xue Liu, Yan Liu, Rui-xue Yang, **ang-jiu Ding, Er-shun Liang in Cell Death & Disease (2022)

Article

Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury

Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorde...

**-**a Hu, Wei-**g Ma, Li-Ying He, Cong-Hui Zhang, Cheng Zhang… in Cell Death & Disease (2022)

Article

Correction: Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

**ao-**g Chen, Yuan-Run Deng, Zi-Ci Wang, Wen-Fei Wei… in Cell Death & Disease (2022)

Article

Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism

Although high-fat diet (HFD) has been implicated in the development of colorectal cancer (CRC), the critical signaling molecule that mediates the cancer growth is not well-defined. Identifying the master regul...

**an**g Hu, Sarwat Fatima, Minting Chen, Keyang Xu, Chunhua Huang… in Cell Death & Disease (2021)

Article

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...

Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen… in Cell Death & Disease (2021)

Article

High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner

Epidemiology studies indicate that consumption of high-fat diet (HFD) is directly associated with the development of colorectal cancer (CRC). However, the exact component in HFD and the mechanism underlying it...

Sarwat Fatima, **an**g Hu, Chunhua Huang, Weixiong Zhang, **g Cai… in Cell Death & Disease (2019)

Article

Signal transducer and activator of transcription-3 drives the high-fat diet-associated prostate cancer growth

Prostate cancer (PCa) is the second leading cause of cancer death in men. PCa progression can be associated with obesity. Signal transducer and activator of transcription-3 (STAT3) plays a crucial role in PCa ...

Hiu Yee Kwan, Bin Liu, Chunhua Huang, Sarwat Fatima, Tao Su… in Cell Death & Disease (2019)

Article

Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

The accumulation of tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is associated with malignant progression in cancer. However, the mechanisms by which the hypoxic TME facili...

**ao-**g Chen, Yuan-Run Deng, Zi-Ci Wang, Wen-Fei Wei… in Cell Death & Disease (2019)

Article

miR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer

Cancer metastasis is the main cause of death in breast cancer (BC) patients. Therefore, prediction and treatment of metastasis is critical for enhancing the survival of BC patients. In this study, we aimed to ...

**n-Ge Zhao, **g-Ye Hu, Jun Tang, Wei Yi, Mei-Yin Zhang, Rong Deng… in Cell Death & Disease (2019)

Article

RETRACTED ARTICLE: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer

Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studi...

Hong-En Yu, Feng Wang, Fang Yu, Zhao-Lei Zeng, Yun Wang, Yun-**n Lu… in Cell Death & Disease (2019)

Article

circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA

Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important pl...

Jia-xiang Zhang, Jian Lu, Hui **e, Da-peng Wang, Huan-er Ni… in Cell Death & Disease (2019)

Article

LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation

Atherosclerotic cardio-cerebrovascular disease and death remain the leading cause of morbidity and mortality worldwide. Defective efferocytosis, the clearance of apoptotic cells by macrophages, is thought to l...

Zi-ming Ye, Shuai Yang, Yuan-peng **a, Rui-ting Hu, Shengcai Chen… in Cell Death & Disease (2019)

Article

Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells

Decidual γδΤ (dγδΤ) cells play an essential role during successful pregnancy; however, the residence and polarization of γδΤ cells in decidua remain unclear. In this study, we observed higher levels of recepto...

Rui-Qi Chang, Jun Shao, Yu-Han Meng, Jian Wang, Da-** Li… in Cell Death & Disease (2019)