West Germany and the Portuguese Dictatorship, 1968–1974
Between Cold War and Colonialism
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Article
Open AccessProstate cancer treatment in Portugal: a nationwide analysis
Different treatment options exist for localized prostate cancer. Treatments performed in high-volume hospitals are associated with better results. Our objective was to describe time trends in prostate cancer t...
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Article
Open AccessCancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens
YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in up...
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Article
Modelling the impact of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin
Strategies targeting nucleolin have enabled a significant improvement in intracellular bioavailability of their encapsulated payloads. In this respect, assessment of the impact of target cell heterogeneity and...
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Article
Open AccessSARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray
There are currently no cures for coronavirus infections, making the prevention of infections the only course open at the present time. The COVID-19 pandemic has been difficult to prevent, as the infection is s...
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Article
Real-time video frame differentiation in multihomed VANETs
Providing high quality video transmission in VANETs is very challenging due to the highly dynamic, unpredictable topology, and low bandwidth characteristics. In this article, we design a system able to optimal...
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Article
Open AccessPAX8 and MECOM are interaction partners driving ovarian cancer
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian...
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Article
Open AccessA comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...
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Article
Orthorexia nervosa and comorbid depression successfully treated with mirtazapine: a case report
Orthorexia nervosa (ON) is a recently proposed eating disordered behaviour characterized by an obsessional or exaggerated fixation on healthy eating. The published literature is scarce regarding its classifica...
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Chapter and Conference Paper
DSS-Based Ontology Alignment in Solid Reference System Configuration
uebe.Q is a managing software for solid referential information systems, such as ISO 9000 (for quality) and ISO 1400 (for environment). This is a long-term developed software, encompassing extensive and solid ...
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Article
The Role of Hypernetworks as a Multilevel Methodology for Modelling and Understanding Dynamics of Team Sports Performance
Despite its importance in many academic fields, traditional scientific methodologies struggle to cope with analysis of interactions in many complex adaptive systems, including team sports. Inherent features of...
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Article
Open AccessPAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we identify PAX8 as a candidate oncog...
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Chapter and Conference Paper
A Different Perspective on the Production and Application of Warm Mix Asphalt Under Unfavorable Temperature Conditions
Warm mix asphalt (WMA) is produced by a variety of technologies at lower temperatures that enable to gain important environmental and social benefits and, in consequence, to contribute to a more sustainable tr...
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Article
Integration of storage systems in distribution networks through multiobjective optimization
The use of storage systems in distribution networks allows smoothing the load diagram. In fact, the cost of energy is different along the day and companies can be encouraged to use these systems, since the ext...
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Protocol
GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression
The advent of next-generation sequencing (NGS) technologies has revolutionized the way we do research on gene expression. High-throughput transcriptomics became possible with the development of microarray tech...
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Article
Applying CRISPR–Cas9 tools to identify and characterize transcriptional enhancers
CRISPR–Cas9-based genome editing tools have been developed recently to study non-coding transcriptional regulatory elements, enabling the characterization of enhancers in their endogenous context. The applicat...
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Article
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading
Tumours can require certain amino acids for their proliferation, and the diricore method described here helps to identify such restrictive amino acids; using this method in kidney cancer tissue and breast carc...
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Article
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
CRISPR-Cas9 is used for both enrichment and dropout screens of functional enhancers in human cells.
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Article
Open AccessGenome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA
p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while many p53-induced enhancers contained p53-bin...
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Article
A case of choking phobia: towards a conceptual approach
Choking phobia, also known as phagophobia or swallowing phobia is an uncommon clinical entity that has been underappreciated and is included in the new DSM-5 and upcoming ICD-11 diagnostic category of avoidant...
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