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  1. Article

    Open Access

    Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors

    Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...

    Sebastian M. Dieter, Domenica Lovecchio, Abhijeet Pataskar, Martina K. Zowada… in Oncogene (2022)

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  2. Article

    Open Access

    A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

    Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...

    Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter… in Genome Biology (2021)

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  3. Article

    Open Access

    The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

    While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the ...

    Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann… in BMC Cancer (2019)

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  4. No Access

    Article

    Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

    Hanno Glimm, Jan Korbel and colleagues present a computational framework called cis expression structural alteration map** (CESAM), which they use to identify somatic copy-number alterations affecting cis-regul...

    Joachim Weischenfeldt, Taronish Dubash, Alexandros P Drainas… in Nature Genetics (2017)