33 Result(s)

Article

Learning and depicting lobe-based radiomics feature for COPD Severity staging in low-dose CT images

Chronic obstructive pulmonary disease (COPD) is a prevalent and debilitating respiratory condition that imposes a significant healthcare burden worldwide. Accurate staging of COPD severity is crucial for patie...

Meng Zhao, Yanan Wu, Yifu Li, **aoyu Zhang, Shuyue **a… in BMC Pulmonary Medicine (2024)

Article

Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease

Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a uniq...

**gyuan Gao, Yuqiong Yang, **aopeng **ang, Huimin Zheng, … in Respiratory Research (2024)

Article

Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma

Asthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with abnormal responses of various cell types in the lung. The specific inter...

**u Yu, Lifei Li, Bicheng Cai, Wei Zhang, Quan Liu, Nan Li… in Respiratory Research (2024)

Article

Impacts of short-term low-level exposure to air pollutants on hospital admissions for pulmonary sepsis in elderly patients

Acute exposures to high levels of air pollutants are thought to be associated with hospitalization of patients with lung infection, while relatively little is known about the association between air pollutants...

**g Chen, Aiming Liu, JunJie Dai, Yichen Li, Yu Zhang… in BMC Pulmonary Medicine (2023)

Article

Prophylactic antibiotics for preventing ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis

The role of prophylactic antibiotics in preventing ventilator-associated pneumonia (VAP) in patients undergoing invasive mechanical ventilation (IMV) remains unclear. This network meta-analysis compared the ef...

Shanshan Zha, Jianyi Niu, Zhenfeng He, Wei Fu… in European Journal of Medical Research (2023)

Article

A rare case of severe leptospirosis infection presenting as septic shock in a non-endemic area: a case report and literature review

Leptospirosis is a zoonosis caused by spirochete “genus” leptospira. The clinical presentations of leptospirosis range from an influenza-like presentation of fever and myalgia, to severe forms. Leptospirosis c...

Junjie Dai, Can Yao, Huaxiang Ling, Binbin Li, Rongchang Chen… in BMC Infectious Diseases (2023)

Article

Low human beta-defensin-2 levels in the sputum of COPD patients are associated with the risk of exacerbations

Chronic obstructive pulmonary disease (COPD) is a complicated chronic inflammatory disease. It is important to investigate the characteristics of acute exacerbation of COPD to develop new therapeutic strategies.

Shengchuan Feng, Yuqiong Yang, Fengyan Wang, Weijuan Shi… in BMC Pulmonary Medicine (2023)

Article

Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study

Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transpl...

Chunrong Ju, **aohua Wang, **n Xu, Shaobo **e, Qingdong Cao… in BMC Infectious Diseases (2022)

Article

Actinomycetes-derived imine reductases with a preference towards bulky amine substrates

Since imine reductases (IREDs) were reported to catalyze the reductive amination reactions, they became particularly attractive for producing chiral amines. Though diverse ketones and aldehydes have been prove...

Jun Zhang, **n Li, Rongchang Chen, **anwei Tan, **ongduo Liu… in Communications Chemistry (2022)

Article

Hypoxic stress suppresses lung tumor-secreted exosomal miR101 to activate macrophages and induce inflammation

Hypoxia promotes inflammation in the tumor microenvironment. Although hypoxia-inducible factor 1α (HIF1α) is a master modulator of the response to hypoxia, the exact mechanisms through which HIF1α regulates th...

Jie Li, Peng Xu, Di Wu, Minjie Guan, Xuanwen Weng, Yongzhen Lu… in Cell Death & Disease (2021)

Article

Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults

Differences between adult patients with severe early-onset and late-onset asthma have not been well studied.

Dandan Chen, Yu Zhang, Can Yao, Binbin Li… in Allergy, Asthma & Clinical Immunology (2021)

Article

Noninvasive ventilation with a helmet in patients with acute respiratory failure caused by chest trauma: a randomized controlled trial

Noninvasive ventilation (NIV) is beneficial in acute respiratory failure (ARF) caused by chest trauma; however, NIV-related complications affect the efficacy. We evaluated whether NIV with helmet decreases the...

Qi Liu, Mengtian Shan, Hailong Zhu, Jianliang Cao, Rongchang Chen in Scientific Reports (2020)

Article

Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19

Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute...

Ramandeep Kaur, Tyler T. Weiss, Andrew Perez, James B. Fink… in Critical Care (2020)

Article

Non-invasive ventilation in the treatment of early hypoxemic respiratory failure caused by COVID-19: considering nasal CPAP as the first choice

Lili Guan, Luqian Zhou, Jehane Michael Le Grange, Zeguang Zheng… in Critical Care (2020)

Article

Efficacy and Safety of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler in Chinese Patients with COPD: A Subgroup Analysis of KRONOS

This pre-specified subgroup analysis evaluated the efficacy and safety of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) triple therapy versus corresponding dual therapies in the ...

Chen Wang, Ting Yang, Jian Kang, Rongchang Chen, Li Zhao, Huijie He… in Advances in Therapy (2020)

Article

Combination of inspiratory and expiratory muscle training in same respiratory cycle versus different cycles in COPD patients: a randomized trial

Difference between combined inspiratory and expiratory muscle training in same respiratory cycle or different cycles remained unclarified. We explored the difference between both patterns of combined trainings...

Wenhui Xu, Rui Li, Lili Guan, Kai Wang, Yuhe Hu, Limei Xu… in Respiratory Research (2018)