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Article
Open AccessMatrix Metalloproteinases in Cytotoxic Lymphocytes Impact on Tumour Infiltration and Immunomodulation
To efficiently combat solid tumours, endogenously or adoptively transferred cytotoxic T cells and natural killer (NK) cells, need to leave the vasculature, traverse the interstitium and ultimately infiltrate t...
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Article
Evidence of inter- and intra-molecular crosslinking of tyrosine residues of calmodulin induced by photo-activation of ruthenium(ii)
Tris(2,2′-bipyridyl)ruthenium(ii) upon illumination with light at a wavelength of 450 nm in the presence of an electron acceptor induces dityrosine crosslinking in proteins.
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Article
Tumor structure and extracellular matrix as a possible barrier for therapeutic approaches using immune cells or adenoviruses in colorectal cancer
In this article we report about the role that tumor structure and extracellular matrix (ECM) may play in immunotherapy and in gene therapy using adenoviruses. We performed studies in a rat model for colorectal...
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Article
The urokinase plasminogen activator system in cancer: Implications for tumor angiogenesis and metastasis
Substantial evidence exists which implicates the urokinase plasminogen activator system [urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibit...
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Article
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
It has been suggested that overexpression of the Bcl-2 oncoprotein in human cancer cells contributes to their resistance to apoptosis induced by chemotherapy. We report here that a novel dipeptidyl proteasome ...
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Article
Identification and partial purification of a human natural killer cell proliferation-inducing factor
Culture supernatants of Concanavalin A activated human peripheral blood mononuclear cells were found to contain a factor which induced proliferative response in normal peripheral blood mononuclear cells. This ...
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Article
Morphologic, immunologic, biochemical, and cytogenetic characteristics of the human glioblastoma-derived cell line, SNB-19
Human glioma-derived cell cultures and lines have proven to be of significant value in the study of the basic properties that contribute to the highly malignant, invasive and angiogenic phenotype of glioblasto...
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Book
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Article
Preface: Tumor invasion and brain cancer
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Article
Reply to the Letter to the editors by A. Maghazachi
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Chapter
Observations of Primary and Secondary Lesions in the Same Patient
Invasive neoplastic growth can lead to cancer metastasis, and cancer mortality is most often related to cancer metastasis rather than the primary lesion (16). In an effort to learn more about human cancer meta...
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Chapter
Immunosuppression by Metastatic Tumors
The role of the immune response in preventing or limiting tumor growth as well as affecting the outcome of tumor metastases has long been debated among cancer biologists. A general consensus has emerged which ...
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Chapter
Selected Aspects of Differentiation in Malignant Neoplastic Growth
It is widely accepted that malignant disease is associated with disorders in differentiation. Indeed, it has been observed that the patient with cancer is a product of abnormal cell differentiation (16). It is...
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Chapter
Oncogene Products as Potential Therapeutic Targets for Control of Established Metastatic Disease
An explosive pace of research has developed in the last several years exploring the role of oncogenes and their products (see preceding Chapters, 10–14, this volume). The potential of elucidating the molecular...
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Chapter
Overview of Current Understanding of Tumor Spread
Progressive stages of malignant neoplastic growth can lead to cancer metastasis which is the major cause of treatment’ failure, moribidity, and death for patients with solid malignant tumors (5, 12, 33, 44, 45...
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Chapter
Proteolytic Enzymes in Tumor Invasion and Degradation of Host Extracellular Matrices
A fact widely recognized by clinical oncologists is that rather than the primary tumor, the secondary metastatic tumor(s) usually leads to the lethality of human malignant disease (1–4). Tumor invasion, the de...
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Chapter
Interaction of Tumor Cells with the Basement Membrane of Endothelium
Intense clinical and experimental interest continues to be placed on cancer invasion and metastasis since these pathologic processes are widely considered to be the major cause of death resulting from malignan...
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Chapter
Mechanisms of Tumor Cell Lysis by Natural Killer Cells
Immune reactivity against malignant cells is well-documented for a number of lymphoid cell types (1). The foremost features of anti-timor immune effector cells appears to be their capacity to recognize and sub...
