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Article
SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury
Diffuse axonal injury (DAI) is a common feature of severe traumatic brain injury (TBI) and may also be a predominant pathology in mild TBI or “concussion”. The rapid deformation of white matter at the instant ...
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Article
Temporal Profiles of Cytoskeletal Protein Loss following Traumatic Axonal Injury in Mice
To examine the time course and relative extent of proteolysis of neurofilament and tubulin proteins after traumatic axonal injury (TAI), anesthetized mice were subjected to optic nerve stretch injury. Immunohi...
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Article
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
It has been suggested that overexpression of the Bcl-2 oncoprotein in human cancer cells contributes to their resistance to apoptosis induced by chemotherapy. We report here that a novel dipeptidyl proteasome ...
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Alzheimer’s Disease
Alzheimer’s disease (AD) is an enormous medical, social, and economic problem. It is characterized by a profound decline in cognition progressing over several years, and is the leading cause of dementia and th...
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Proteases and Pathological Neurodegeneration
An understanding of the biochemical processes that lead to neuronal damage is crucial to the development of therapies aimed at slowing the progression of neurodegenerative diseases. While brain proteases have ...
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Article
Regulation of glutamate receptor binding by the cytoskeletal protein fodrin
The erythrocyte cytoskeleton, which consists primarily of a mesh-work of spectrin and actin, controls cell shape and the disposition of proteins within the membrane1–3. Proteins similar to spectrin have recently ...
