SpringerLink
Log in

Selected Aspects of Differentiation in Malignant Neoplastic Growth

  • Chapter
Influence of the Host on Tumor Development

Part of the book series: Cancer Growth and Progression ((CAGP,volume 4))

  • 40 Accesses

Abstract

It is widely accepted that malignant disease is associated with disorders in differentiation. Indeed, it has been observed that the patient with cancer is a product of abnormal cell differentiation (16). It is therefore likely that an understanding of cellular differentiation and an understanding of the development of neoplasia can lead to new strategies for the diagnosis and therapy of malignant disease. Many experimental research areas have been explored in the study of differentiation and cancer including: genetic control; chromosome abnormalities; growth regulation of malignant tumor cells; differentiation of stem cells; and the regulation of differentiation as a potential therapeutic modality (1, 21, 24, 25). This chapter will review molecular and cellular aspects of differentiation, its relevance to tumor progression and malignancy, and discuss the significance of these findings to therapeutic approaches for the control of malignant diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (Canada)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (Canada)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (Canada)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Andersson LC, Gahmberg CG, Ekblom P, (Eds.). Gene Expression During Normal and Malignant Differentiation. Academic Press, London (1985)

    Google Scholar 

  2. Aubert C, Rouge F, Galindo JR: Differentiation and tumorigenicity of human malignant melancoytes in relation to their culture conditions. J Natl Cancer Inst 72:3, 1984

    PubMed  CAS  Google Scholar 

  3. Bennett DC, Dexter TJ, Ormerod EJ, Hart IR: Increased experimental capacity of a murine melanoma following induction of differentiation. Cancer Res 46:3239, 1986

    PubMed  CAS  Google Scholar 

  4. Cheson BD, Jasperse DE, Chun HG, Friedman MA: Differentiating agents in the treatment of human malignancies. Cancer Treatment Rep 13:129, 1986

    Article  CAS  Google Scholar 

  5. Daenen S, Vellenga E, van Dobbenburgh OA, Halie MR: Retinoic acid as antileukemic therapy in a patient with acute promyelocytic leukemia and Aspergillus pneumonia. Blood 67:559, 1986

    CAS  Google Scholar 

  6. Fearon ER, Burke PJ, Schiffer A, Zehnbauer BA, Vogelstein B: Differentiation of leukemia cells to polymorphonuclear leukoytes in patients with acute nonlymphocytic leukemia. New Engl J Med 315:15, 1986

    Article  PubMed  CAS  Google Scholar 

  7. Ford RJ, Maizel AL (Eds.): Mediators in Cell Growth and Differentiation. Raven Press, New York, 1985

    Google Scholar 

  8. Gabbert H: Mechanisms of tumor invasion: evidence from in vivo observations. Cancer and Metastasis Reviews 4:293, 1985

    Article  PubMed  CAS  Google Scholar 

  9. Gabbert H, Wagner R, Moll R, Gerharz C-D: Tumor dedifferentiation: an important step in tumor invasion. Clin Expl Metastasis 3:257, 1985

    Article  CAS  Google Scholar 

  10. Goldfarb RH: Plasminogen activators. Ann Rep Med Chem 18:257, 1983

    Article  CAS  Google Scholar 

  11. Goldfarb RH: Proteolytic enzymes in tumor invasion and degradation of host extracellular matrices. In. KV Honn, WE Powers, BF Sloane (Eds.). Mechanisms of Cancer Metastasis: Potential Therapeutic Implications. Martinus Nijhoff, Boston, p 341, 1986

    Google Scholar 

  12. Goldfarb RH, Brunson KW: Overview of current understanding of tumor spread. In: HE Kaiser (Ed.). Cancer Growth and Progression, Vol I, Martinus Nijhoff, Boston, 1988

    Google Scholar 

  13. Goldfarb RH, Herberman RB: Natural killer cell reactivity: Regulatory interactions among phorbol ester, interferon, cholera toxin and retinoic acid. J Immunol 126:2129, 1981

    PubMed  CAS  Google Scholar 

  14. Jetten AM: Modulation of cell growth by retinoids and their possible mechanisms of action. Federation Proc 43:134, 1984

    CAS  Google Scholar 

  15. Jetten AM, Goldfarb RH: Action of epidermal growth factor and retinoids on anchorage-dependent and -independent growth on nontransformed rat kidney cells. Cancer Res 43:2094, 1983

    PubMed  CAS  Google Scholar 

  16. Jetten AM, Jetten MER: Possible role of retinoic acid binding protein in retinoid stimulation of embryonal carcinoma cell differentiation. Nature 278:180, 1979

    Article  PubMed  CAS  Google Scholar 

  17. Kennedy BJ: Clinical oncology and cell differentiation. In: RG McKinnel, MA DiBerardino, M Blumenfield, RD Bergad (Eds.). Differentiation and Neoplasia. Springer Verlag, Berlin, p. 298, 1980

    Google Scholar 

  18. Laiho M, Saksela O, Keski-Oja J: Transforming growth factor Beta alters plasminogen activator activity in human skin fibrobasts. Exp Cell Res 164:399, 1986

    Article  PubMed  CAS  Google Scholar 

  19. Marks PA, Rifkind RA: Erythroleukemic Differentiation. Ann Rev Biochem 47:419, 1978

    Article  PubMed  CAS  Google Scholar 

  20. Marks PA, Sheffery M, Rifkind RA: Induction of transformed cells to terminal differentiation and modulation of gene expression. Cancer Res 47:659, 1987

    PubMed  CAS  Google Scholar 

  21. Masui T, Wakefield L, Lechner JF, La Veck MA, Sporn MB, Harris CC: Type B transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc Natl Acad Sci USA 83:2438, 1986

    Article  PubMed  CAS  Google Scholar 

  22. McKinnel RG, DiBernardino MA, Blumenfield M, Bergad RD (Eds.). Differentiation and Neoplasia. Springer Verlag, Berlin. 1980.

    Google Scholar 

  23. Moore MAS: Biologicals for cancer treatment: Growth and differentiating agents. Hosptial Practice. Feb. 15, 1986: p. 69, 1986

    Article  Google Scholar 

  24. Muller R: Proto-oncogenes and differentiation. TIBS, 11: March, 1986, p. 129, 1986

    Google Scholar 

  25. Murakami H, Yamane I, Barnes DW, Mather JP, Hayashi I, Sato GH (Eds.). Proceedings of the International Symposium on Growth and Differentiation of Cells in Defined Environment. Kodansha Ltd. (Springer Verlag), Tokyo, 1985.

    Google Scholar 

  26. Nakahara W, Ono T, Sugimura T, Suano H (Eds.). Differentiation and Control of Malignancy of Tumor Cells (Proc. 4th Int. Symposium of the Princess Takamatsu Cancer Research Fund). University Park Press, Baltimore, 1974.

    Google Scholar 

  27. Ossowski L, Berlin D: Effect of dimethyl sulfoxide on human cacinoma cells, inhibition of plasminogen activator synthesis, change in cell morphology, and alteration of response to cholera toxin. Mol Cell Biol 5:3553, 1985

    Google Scholar 

  28. Reiss M, Gamba-Vitalo C, Sartorelli AC: Induction of tumor cell differentiation as a therapeutic approach: Preclinical models for hematopoietic and solid neoplasms. Cancer Treatment Reports 70:201, 1986

    PubMed  CAS  Google Scholar 

  29. Rifkind RA: Acute leukemia and cell differentiation. New Engl J Med 315:56, 1986

    Article  PubMed  CAS  Google Scholar 

  30. Rifkind RA, Sheffrey M, Marks PA: Induced differentiation of murine erythroleukemia cells: Cellular and molecular mechanisms. Adv Cancer Res 42:149, 1984

    Article  PubMed  CAS  Google Scholar 

  31. Sachs L: Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia. 274:535, 1978

    CAS  Google Scholar 

  32. Sachs L: Constitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia: A model for the origin and progression of malignancy. Proc Natl Acad Sci USA 77:6152, 1980

    Article  PubMed  CAS  Google Scholar 

  33. Sachs L: Induction of normal differentiation in malignant cells as an approach to cancer therapy. In: AC Sartorelli, JS Lazo, JR Bertino (Eds.). Molecular Actions and Targets for Cancer Chemotherapeutic Agents. Academic Press, New York. p. 579, 1981

    Google Scholar 

  34. Sachs L: Cell differentiation and bypassing of genetic defects in the suppression of malignancy. Cancer Res 47:1981, 1987

    PubMed  CAS  Google Scholar 

  35. Sartorelli AC: Malignant cell differentiation as a potential therapeutic approach. Br J Cancer 52:293, 1985

    Article  PubMed  CAS  Google Scholar 

  36. Sartorelli AC, Morin MJ, Ishiguro K: Cancer chemotherapeutic agents of leukemia cell differentiation. In: KR Harrap and TA Connors (Eds.) New Avenues in Developmental Cancer Chemotherapy. Academic Press, New York, pp. 187–204, 1987

    Google Scholar 

  37. Scott RE, Maercklein PB: An initiator of carcinogenesis selectively and stably inhibits stem cell differentiation: A concept that initiation of carcinogenesis involves multiple phases. Proc Natl Acad Sci USA 82:2995, 1985

    Article  PubMed  CAS  Google Scholar 

  38. Sparks RL, Scott RE: Transforming growth factor type Beta is a specific inhibitor of 3T3 mesenchymal stem cell differentiation. Exp Cell Res 345, 1986

    Google Scholar 

  39. Sporn MB, Roberts AB: Role of retinoids in differentiation and carcinogenesis. Cancer Res 43:3034, 1983

    PubMed  CAS  Google Scholar 

  40. Sporn MB, Roberts AB: Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Investig 78:329, 1986

    Article  PubMed  CAS  Google Scholar 

  41. Strickland S: Induction of Differentiation by Retinoids. In: GH Sato, R Ross (Eds.). Cold Spring Harbour Conferences on Cell Proliferation. Volume 6. Hormones and Cell Culture. Cold Spring Habour Laboratory. p. 671, 1979

    Google Scholar 

  42. Stickland S, Mahdavi V: The induction of differentiation in tseratocarcinoma stem cells by retinoic acid. Cell 15:393, 1978

    Article  Google Scholar 

  43. Weir ML, Scott RE: Defective control of terminal differentiation and its role in carcinogenesis in the 3T3 T proadipocyte stem cell line. Cancer Res 45:3339, 1985

    Google Scholar 

  44. Weir ML, Scott RE: Regulation of the terminal event in cellular differentiation: Biological mechanisms of the loss of proliferative potential. J Cell Biol 102:1955, 1986

    Article  Google Scholar 

Download references

Authors
  1. Ronald H. Goldfarb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenneth W. Brunson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pittsburgh Cancer Institute, Pittsburgh, Pa., USA

    Ronald B. Herberman

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers, Dordrecht

About this chapter

Cite this chapter

Goldfarb, R.H., Brunson, K.W. (1989). Selected Aspects of Differentiation in Malignant Neoplastic Growth. In: Herberman, R.B. (eds) Influence of the Host on Tumor Development. Cancer Growth and Progression, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2530-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-2530-4_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7643-2

  • Online ISBN: 978-94-009-2530-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation