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  1. No Access

    Article

    Structural basis of HIV-1 resistance to AZT by excision

    AZT is a nucleoside analog drug that inhibits HIV-1 reverse transcriptase (RT). The viral enzyme can acquire AZT resistance by mutations that enhance the rate of ATP-mediated excision of the incorporated AZT. ...

    **ongying Tu, Kalyan Das, Qianwei Han… in Nature Structural & Molecular Biology (2010)

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    Article

    Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

    Tenofovir, also known as PMPA, R-9-(2-(phosphonomethoxypropyl)adenine, is a nucleotide reverse transcriptase (RT) inhibitor. We have determined the crystal structures of two related complexes of HIV-1 RT with tem...

    Steve Tuske, Stefan G Sarafianos… in Nature Structural & Molecular Biology (2004)

  3. No Access

    Article

    Bombyx mori single repeat telomeric DMA sequence forms a G-quadruplex capped by base triads

    A combined NMR–molecular dynamics approach has been applied to determine the solution structure of a truncated analogue of the Bombyx mori telomeric d(TTAGG) single repeat sequence in Na+ cation-containing aqueou...

    Abdelali Kettani, Serge Bouaziz, Weimin Wang, Roger A. Jones… in Nature Structural Biology (1997)