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  1. No Access

    Article

    Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias

    Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mut...

    Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski… in Nature Cancer (2023)

  2. No Access

    Article

    PROBER identifies proteins associated with programmable sequence-specific DNA in living cells

    DNA–protein interactions mediate physiologic gene regulation and may be altered by DNA variants linked to polygenic disease. To enhance the speed and signal-to-noise ratio (SNR) in the identification and quant...

    Smarajit Mondal, Muthukumar Ramanathan, Weili Miao, Robin M. Meyers… in Nature Methods (2022)

  3. No Access

    Article

    A genome-wide atlas of co-essential modules assigns function to uncharacterized genes

    A central question in the post-genomic era is how genes interact to form biological pathways. Measurements of gene dependency across hundreds of cell lines have been used to cluster genes into ‘co-essential’ p...

    Michael Wainberg, Roarke A. Kamber, Akshay Balsubramani, Robin M. Meyers… in Nature Genetics (2021)

  4. No Access

    Article

    Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

    CERES is a new computational method to estimate gene-dependency levels from CRISPR–Cas9 essentiality screens while accounting for copy number effects and variable sgRNA activity. Applying CERES to new genome-s...

    Robin M Meyers, Jordan G Bryan, James M McFarland, Barbara A Weir… in Nature Genetics (2017)

  5. No Access

    Article

    Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing

    This protocol describes a genome-wide method to detect and to quantify DNA double-stranded breaks (DSBs). The approach is applicable to endogenous DSBs, but it can also be used to characterize the activity of ...

    Jiazhi Hu, Robin M Meyers, Junchao Dong, Rohit A Panchakshari… in Nature Protocols (2016)

  6. No Access

    Article

    Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

    High-throughput genome-wide sequencing reveals why class switch recombination in the IgH locus, an essential step in the process of antibody generation, has a directional joining bias towards deletion rather t...

    Junchao Dong, Rohit A. Panchakshari, Tingting Zhang, Yu Zhang, Jiazhi Hu… in Nature (2015)

  7. No Access

    Article

    Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

    An unbiased genome-wide method reveals on- and off-target DNA cleavage by TALEN and Cas9 nucleases by detecting chromosome translocation events.

    Richard L Frock, Jiazhi Hu, Robin M Meyers, Yu-Jui Ho, Erina Kii… in Nature Biotechnology (2015)

  8. No Access

    Article

    Microbial colonization influences early B-lineage development in the gut lamina propria

    Primary B-cell development is thought to be restricted to the bone marrow; here it is shown to occur also in intestinal tissues of postnatal mice, that it peaks at the time of weaning and is increased upon col...

    Duane R. Wesemann, Andrew J. Portuguese, Robin M. Meyers, Michael P. Gallagher… in Nature (2013)