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Article
Open AccessHigh-dimensional map** of human CEACAM1 expression on immune cells and association with melanoma drug resistance
Human carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is an inhibitory cell surface protein that functions through homophilic and heterophilic ligand binding. Its expression on immune cells in huma...
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Article
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform
Identification of CD8+ T cell epitopes is critical for the development of immunotherapeutics. Existing methods for major histocompatibility complex class I (MHC class I) ligand discovery are time intensive, speci...
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Article
Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein
The Omicron subvariant BA.2 has become the dominant circulating strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in many countries. Here, we have characterized structural, functional and ...
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Article
Open AccessGenetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
The chr12q24.13 locus encoding OAS1–OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locu...
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Chapter
Molecular Mechanisms of IgE Class Switch Recombination
Immunoglobulin (Ig) E is the most tightly regulated of all Ig heavy chain (IgH) isotypes and plays a key role in atopic disease. The gene encoding for IgH in mature B cells consists of a variable region exon—a...
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Article
Microbial colonization influences early B-lineage development in the gut lamina propria
Primary B-cell development is thought to be restricted to the bone marrow; here it is shown to occur also in intestinal tissues of postnatal mice, that it peaks at the time of weaning and is increased upon col...
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Article
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks
The loss of a classical non-homologous end-joining (NHEJ) repair factor, XLF, shows strong effects in non-lymphoid cells, but in lymphoid cells its absence surprisingly has only modest effects on V(D)J recombi...
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Article
Mechanisms promoting translocations in editing and switching peripheral B cells
Variable, diversity and joining gene segment (V(D)J) recombination assembles immunoglobulin heavy or light chain (IgH or IgL) variable region exons in develo** bone marrow B cells, whereas class switch recom...
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Article
Erratum: TRADD interacts with STAT1-α and influences interferon-γ signaling
Nature Immunology 5, 199–207 (2004). On page 204, column 2, line 3, the number should read “(1,700%).” Nature Immunology regrets the error.
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Article
Correction: Corrigendum: TRADD interacts with STAT1-α and influences interferon-γ signaling
Nature Immunology 5, 199–207 (2004). Figure 3b should have a line separating the top and bottom halves.
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Article
TRADD interacts with STAT1-α and influences interferon-γ signaling
Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is essential in recruiting signaling molecules to the TNFR1 receptor complex. Interferon-γ (IFN-γ) is a potent activator of macr...
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Chapter
Erratum to: Interaction of STAT Signals with Other Signaling Pathways
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Interaction of STAT Signals with Other Signaling Pathways
Since the discovery of the STAT proteins, there have been a great many reports on the involvement of STAT signals with other signaling pathways. These interactions can be classified into at least four general ...
