30 Result(s)

Article

Nociceptor-immune interactomes reveal insult-specific immune signatures of pain

Inflammatory pain results from the heightened sensitivity and reduced threshold of nociceptor sensory neurons due to exposure to inflammatory mediators. However, the cellular and transcriptional diversity of i...

Aakanksha Jain, Benjamin M. Gyori, Sara Hakim, Ashish Jain, Liang Sun… in Nature Immunology (2024)

Article

Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice

Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocytes; however, fundamental features of these cells are poorly understood. Here we show tha...

Timothy M. O’Shea, Yan Ao, Shinong Wang, Yilong Ren, Amy L. Cheng… in Nature Neuroscience (2024)

Article

Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus

Severe psychiatric illnesses, for instance schizophrenia, and affective diseases or autism spectrum disorders, have been associated with cognitive impairment and perturbed excitatory-inhibitory balance in the ...

Yasmina Curto, Héctor Carceller, Patrycja Klimczak… in Molecular Psychiatry (2024)

Article

Crym-positive striatal astrocytes gate perseverative behaviour

Astrocytes are heterogeneous glial cells of the central nervous system^1–3. However, the physiological relevance of astrocyte diversity for neural circuits and behaviour remains unclear. Here we show that a specif...

Matthias Ollivier, Joselyn S. Soto, Kay E. Linker, Stefanie L. Moye… in Nature (2024)

Article

A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons

The brain controls nearly all bodily functions via spinal projecting neurons (SPNs) that carry command signals from the brain to the spinal cord. However, a comprehensive molecular characterization of brain-wi...

Carla C. Winter, Anne Jacobi, Junfeng Su, Leeyup Chung, Cindy T. J. van Velthoven… in Nature (2023)

Article

A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences

Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function. Genetically manipulating astrocytes is an essential tool in understanding and a...

Amy J. Gleichman, Riki Kawaguchi, Michael V. Sofroniew… in Nature Communications (2023)

Article

Erythropoietin re-wires cognition-associated transcriptional networks

Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO remained obscure. Here, we pr...

Manvendra Singh, Ying Zhao, Vinicius Daguano Gastaldi… in Nature Communications (2023)

Article

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

The incidence of Alzheimer’s disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocy...

Constanze Depp, Ting Sun, Andrew Octavian Sasmita, Lena Spieth… in Nature (2023)

Article

Author Correction: Divergent transcriptional regulation of astrocyte reactivity across disorders

Joshua E. Burda, Timothy M. O’Shea, Yan Ao, Keshav B. Suresh, Shinong Wang… in Nature (2023)

Article

Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD

Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has demonstrated dysregulation at the molecular level, characterized by transcriptomic and epigenetic alterations^1–3. In aut...

Michael J. Gandal, Jillian R. Haney, Brie Wamsley, Chloe X. Yap, Sepideh Parhami… in Nature (2022)

Article

P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells

Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and...

Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair… in Nature Communications (2022)

Article

Elk-1 regulates retinal ganglion cell axon regeneration after injury

Adult central nervous system (CNS) axons fail to regenerate after injury, and master regulators of the regenerative program remain to be identified. We analyzed the transcriptomes of retinal ganglion cells (RG...

Takahiko Noro, Sahil H. Shah, Yuqin Yin, Riki Kawaguchi… in Scientific Reports (2022)

Article

Clinically relevant small-molecule promotes nerve repair and visual function recovery

Adult mammalian injured axons regenerate over short-distance in the peripheral nervous system (PNS) while the axons in the central nervous system (CNS) are unable to regrow after injury. Here, we demonstrated ...

Ngan Pan Bennett Au, Gajendra Kumar, Pallavi Asthana… in npj Regenerative Medicine (2022)

Article

Transcriptomic architecture of nuclei in the marmoset CNS

To understand the cellular composition and region-specific specialization of white matter — a disease-relevant, glia-rich tissue highly expanded in primates relative to rodents — we profiled transcriptomes of ...

**g-** Lin, Hannah M. Kelly, Yea** Song, Riki Kawaguchi… in Nature Communications (2022)

Article

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice

The inability of neurons to regenerate long axons within the CNS is a major impediment to improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances have uncovered an intrinsic ...

Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M. Bernstein… in Nature Communications (2022)

Article

The effect of Rbfox2 modulation on retinal transcriptome and visual function

Rbfox proteins regulate alternative splicing, mRNA stability and translation. These proteins are involved in neurogenesis and have been associated with various neurological conditions. Here, we analyzed Rbfox2...

Lei Gu, Riki Kawaguchi, Joseph Caprioli, Natik Piri in Scientific Reports (2020)