-
Article
Open AccessBroad transcriptomic dysregulation occurs across the cerebral cortex in ASD
Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has demonstrated dysregulation at the molecular level, characterized by transcriptomic and epigenetic alterations1–3. In aut...
-
Article
Open AccessAssociation between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder
Gene expression covaries with brain activity as measured by resting state functional magnetic resonance imaging (MRI). However, it is unclear how genomic differences driven by disease state can affect this rel...
-
Article
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
The most significant common variant association for schizophrenia (SCZ) reflects increased expression of the complement component 4A (C4A). Yet, it remains unclear how C4A interacts with other SCZ risk genes or w...
