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Article
Open AccessPreviously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland
Predisposing factors underlying familial aggregation of non-syndromic gliomas are still to be uncovered. Whole-exome sequencing was performed in four Finnish families with brain tumors to identify rare predisp...
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Article
Open AccessGenomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting
As the progression of low-grade diffuse astrocytomas into grade 4 tumors significantly impacts patient prognosis, a better understanding of this process is of paramount importance for improved patient care. In...
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Article
Open AccessGermline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families
BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in ...
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Article
Open AccessScreening of Finnish RAD51Cfounder mutations in prostate and colorectal cancer patients
Rare, heterozygous germline mutations in the RAD51C gene have been found in breast and ovarian cancer families. In the Finnish population, we have identified two founder mutations in RAD51C that increase the risk...
