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  1. No Access

    Article

    Exogenous control of mammalian gene expression through modulation of RNA self-cleavage

    Recent studies on the control of specific metabolic pathways in bacteria have documented the existence of entirely RNA-based mechanisms for controlling gene expression. These mechanisms involve the modulation ...

    Laising Yen, Jennifer Svendsen, Jeng-Shin Lee, John T. Gray, Maxime Magnier… in Nature (2004)

  2. No Access

    Article

    Dystrophin expression in the mdx mouse restored by stem cell transplantation

    The development of cell or gene therapies for diseases involving cells that are widely distributed throughout the body has been severely hampered by the inability to achieve the disseminated delivery of cells ...

    Emanuela Gussoni, Yuko Soneoka, Corinne D. Strickland, Elizabeth A. Buzney… in Nature (1999)

  3. No Access

    Article

    Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

    The cytokine interleukin-3 (IL-3), which can be derived from T cells and other sources, is a potentially important link between the immune and haematopoietic systems1. IL-3 may be particularly critical for the de...

    Chris S. Lantz, Jurg Boesiger, Chang Ho Song, Nicolas Mach, Takahiko Kobayashi… in Nature (1998)

  4. No Access

    Article

    Physiological consequences of loss of plasminogen activator gene function in mice

    Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactiva...

    Peter Carmeliet, Luc Schoonjans, Lena Kieckens, Beverly Ream, Jay Degen… in Nature (1994)

  5. Article

    Correction: Negative regulation of human c-fos expression by the retinoblastoma gene product

    Nature 346, 668-671 (1990) THIS letter in the 16 August 1990 issue of Nature reported that the protein product of the retinoblastoma susceptibility gene (RB-1) can repress c-fos expression and AP-1 transcripti...

    Paul D. Robbins, Jonathan M. Horowitz, Richard C. Mulligan in Nature (1991)

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  6. No Access

    Article

    Negative regulation of human c-fos expression by thes retinoblastoma gene product

    INACTIVATION of the retinoblastoma susceptibility gene (RB-1) has been associated with the aetiology of many types of human cancers, leading to the classification of RB-1 as an anti-oncogene or tumour suppressor...

    Paul D. Robbins, Jonathan M. Horowitz, Richard C. Mulligan in Nature (1990)

  7. No Access

    Article

    Lineage-specific expression of a human β-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells

    Recombinant retroviral genomes encoding a chromosomal human β-globin gene have been used to transduce murine haematopoietic stem cells in vitro. After permanent engraftment oflethally irradiated recipients with t...

    Elaine A. Dzierzak, Thalia Papayannopoulou, Richard C. Mulligan in Nature (1988)

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    Article

    Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

    An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow t...

    David A. Williams, Ihor R. Lemischka, David G. Nathan, Richard C. Mulligan in Nature (1984)

  9. No Access

    Article

    Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome

    Rabbit β-globin complementary DNA (cDNA) has been inserted into SV40DNA in place of the gene coding for the virus' major capsid protein, VP1. The recombinant genome, SVGT5-RaβG, multiplies efficiently in CV1 m...

    Richard C. Mulligan, Bruce H. Howard, Paul Berg in Nature (1979)