41 Result(s)

Article

Advances in Sickle Cell Therapies in the Hydroxyurea Era

In the hydroxyurea era, insights into mechanisms downstream of erythrocyte sickling have led to new therapeutic approaches for patients with sickle cell disease (SCD). Therapies have been developed that target...

Joshua J. Field, David G. Nathan in Molecular Medicine (2014)

Article

Musings on genome medicine: Hepatitis C

Hepatitis C is a viral disease transmitted principally by blood, which affects millions of people worldwide. A significant proportion of those affected develop severe liver disease as a result. Only a fraction...

David G Nathan, Stuart H Orkin in Genome Medicine (2010)

Article

Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases

The lysosomal storage diseases, such as Gaucher's disease, mucopolysaccharidosis I, II and IV, Fabry's disease, and Pompe's disease, are rare inherited disorders whose symptoms result from enzyme deficiency ca...

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: Crohn's disease

The inflammatory bowel diseases, Crohn's disease and ulcerative colitis, pose a fascinating challenge to specialists in gastroenterology, infectious diseases, immunology and genetics and an often crushing burd...

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: the slow but inexorable process of medical care reform in the United States

The current healthcare system in the United States is unsustainable, but any attempts at improvement must be carefully managed to avoid weakening the country's contribution to biomedical science research and t...

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: the Obama effect redux

From the point of view of genome medicine, Barack Obama has made two vital policy decisions: he has chosen a new director of the National Institutes of Health, and his proposed change in United States healthca...

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: cholesterol and coronary artery disease

Cholesterol levels and not inflammatory markers are the major variables that pose a risk of coronary artery disease. Diabetes greatly increases the risk at any cholesterol level. Coronary artery disease and ca...

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: cancer genetics and the promise of effective treatment

Cancer is the most common acquired genetic disease. Great progress has been made in documenting the genetic abnormalities that cause the disease, and in the future each tumor will be subjected to genetic analy...

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: gene therapy

Though the field has moved with glacial speed, gene therapies have been carried out successfully in patients with bone marrow disorders including immune deficiencies. The field may be poised to move forward mo...

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: the Obama effect

The inauguration of the Obama administration is likely to enhance the role of genome medicine in clinical care and national economics.

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: abuse of genetic tests

The wide general publication of a putative genetic test for athletic supremacy is clearly an abuse of genetics and reveals an undercurrent of hucksterism in biomedical science.

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Musings on genome medicine: genome wide association studies

David G Nathan, Stuart H Orkin in Genome Medicine (2009)

Article

Fred S. Rosen (1930–2005)

Immunologist, paediatrician and polymath

Walter Gratzer, David G. Nathan in Nature (2005)

Article

Acceptance of the 2003 John Howland Award: A Journey in Clinical Research

David G Nathan in Pediatric Research (2004)

Article

A revived opportunity for fetal research

One of President Bill Clinton's early decisions was to lift the ban on federally supported research on human fetal tissue. Under what circumstances can research on this material be justified?

Diana W. Bianchi, Merton Bernfield, David G. Nathan in Nature (1993)

Article

Regulation of Hematopoiesis

David G Nathan in Pediatric Research (1990)

Article

THE REGULATION OF HUMAN ERYTHROPOIESIS BY GROWTH FACTORS

David G Nathan, Bernard Mathey-Prevot, Charlotte M Niemeyer… in Pediatric Research (1988)