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Open AccessProtocol for a pragmatic trial of Cannabidiol (CBD) to improve chronic pain symptoms among United States Veterans
Chronic pain affects over 100 million Americans, with a disproportionately high number being Veterans. Chronic pain is often difficult to treat and responds variably to medications, with many providing minimal...
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Open AccessAuthor Correction: Io’s polar volcanic thermal emission indicative of magma ocean and shallow tidal heating models
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Evidenzbasierte Interventionen zur Behandlung von chronischem Schmerz im unteren Rücken – Therapieauswahl für einen personalisierten Behandlungsansatz
Chronischer Schmerz im unteren Rücken („chronic low back pain“ [cLBP]) hat in den Vereinigten Staaten und auch weltweit eine hohe Prävalenz. Er führt zu funktioneller Beeinträchtigung und verringert die Lebens...
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Open AccessSelf-guided digital acceptance and commitment therapy for fibromyalgia management: results of a randomized, active-controlled, phase II pilot clinical trial
Although empirically validated for fibromyalgia (FM), cognitive and behavioral therapies, including Acceptance and Commitment Therapy (ACT), are inaccessible to many patients. A self-guided, smartphone-based A...
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Limitations of Noninvasive Tests-Based Population-Level Risk Stratification Strategy for Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are highly prevalent but underdiagnosed.
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Open AccessIo’s polar volcanic thermal emission indicative of magma ocean and shallow tidal heating models
The distribution of Io’s volcanic activity probably reflects the position and magnitude of internal tidal heating, but full map** of the moon has not been possible due to a lack of polar coverage. Here we us...
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Open AccessClonal selection of hematopoietic stem cells after gene therapy for sickle cell disease
Gene therapy (GT) provides a potentially curative treatment option for patients with sickle cell disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials has prompted concern, with ...
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Article
Open AccessGenetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling
We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. A goal of this approach is to increase...
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Open AccessP2X7 receptor antagonism by AZ10606120 significantly reduced in vitro tumour growth in human glioblastoma
Glioblastomas are highly aggressive and deadly brain tumours, with a median survival time of 14–18 months post-diagnosis. Current treatment modalities are limited and only modestly increase survival time. Effe...
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Open AccessHematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy
Blood-brain barrier disruption marks the onset of cerebral adrenoleukodystrophy (CALD), a devastating cerebral demyelinating disease caused by loss of ABCD1 gene function. The underlying mechanism are not well un...
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Open AccessMission to Psyche: Including Undergraduates and the Public on the Journey to a Metal World
The NASA Psyche mission’s program to engage university undergraduates and the public in the mission is inspired by and built upon the extensive foundation of public engagement, educational outreach activities,...
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Geology of Io
Io is the most volcanically active object in the Solar System beyond Earth. This tidally-heated moon manifests its activity via >400 volcanic vents (many of which have been active since spacecraft observations...
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Article
Flexible fieldwork
GeoSPACE is addressing the barrier of inaccessible field courses with a planetary mission approach, combining online participation with accessible in-person field work.
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Opportunities to Improve Long COVID Care: Implications from Semi-structured Interviews with Black Patients
Long coronavirus disease (COVID) is an emerging condition that could considerably burden healthcare systems. Prior qualitative studies characterize the experience of having long COVID, which is valuable for in...
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Advocacy for research starting early in the life course
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Open AccessValidation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects
RAS mutations prevalent in high-risk leukemia have been linked to relapse and chemotherapy resistance. Efforts to directly target RAS proteins have been largely unsuccessful. However, since RAS-mediated transf...
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Open AccessCorrection to: The Psyche Topography and Geomorphology Investigation
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Open AccessThe Psyche Topography and Geomorphology Investigation
Detailed map** of topography is crucial for the understanding of processes sha** the surfaces of planetary bodies. In particular, stereoscopic imagery makes a major contribution to topographic map** and ...
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Article
Open AccessA mixed methods analysis of cannabis use routines for chronic pain management
The wide heterogeneity of available cannabis products makes it difficult for physicians to appropriately guide patients. In the current study, our objective was to characterize naturalistic cannabis use routin...
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Open AccessProudman resonance with tides, bathymetry and variable atmospheric forcings
Proudman resonance is a primary amplification mechanism for meteotsunamis, which are shallow-water waves generated by atmospheric forcings. The effect of tides, slo** bathymetry and the speed, amplitude and ...
