32 Result(s)
within
Richard C. Mulligan
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Chapter
Application of Functional Neuroimaging to Examination of Nicotine Dependence
Functional neuroimaging approaches have advanced the field of nicotine and tobacco research by making it possible to study neurobiological mechanisms associated with behaviors predictive of nicotine dependence...
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Article
A fMRI Study of Verbal Working Memory, Cardiac Output, and Ejection Fraction in Elderly Patients with Cardiovascular Disease
Cardiovascular disease (CVD) is associated with cognitive deficits even in the absence of stroke. We examined the relationship between cardiac performance, as measured by cardiac output (CO) and ejection fract...
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Article
Genetically engineered T cells to target EGFRvIII expressing glioblastoma
Glioblastoma remains a significant therapeutic challenge, warranting further investigation of novel therapies. We describe an immunotherapeutic strategy to treat glioblastoma based on adoptive transfer of gene...
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Article
Correction: Corrigendum: VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Nat. Med. 12, 793–800 (2006); published online 25 June 2006; corrected after print 6 April 2009 In the version of this article initially published, the name of one of the authors, Nihar R. Nayak, was misspelle...
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Protocol
A Mammalian Cell-Based Assay for Screening Inhibitors of RNA Cleavage
RNA cleavage is a catalytic reaction which defines many types of RNA processing events, including those of metabolite-sensing riboswitch, self-splicing introns, mRNA splicing, tRNA processing, polyA-cleavage, ...
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Article
Neural Correlates of Visuospatial Working Memory in Healthy Young Adults at Risk for Hypertension
Family history of hypertension (FH+) has been associated with subtle deficits in cognitive function. In search of an early marker that may identify individuals predisposed to develo** cognitive difficulties,...
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Article
Exogenous control of mammalian gene expression via modulation of translational termination
Here, we describe a system for the exogenous control of gene expression in mammalian cells that relies on the control of translational termination. To achieve gene regulation, we modified protein-coding sequen...
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Article
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Vascular endothelial growth factor (VEGF) exerts crucial functions during pathological angiogenesis and normal physiology. We observed increased hematocrit (60–75%) after high-grade inhibition of VEGF by diver...
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Article
Engineering vascularized skeletal muscle tissue
One of the major obstacles in engineering thick, complex tissues such as muscle is the need to vascularize the tissue in vitro. Vascularization in vitro could maintain cell viability during tissue growth, induce ...
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Article
Exogenous control of mammalian gene expression through modulation of RNA self-cleavage
Recent studies on the control of specific metabolic pathways in bacteria have documented the existence of entirely RNA-based mechanisms for controlling gene expression. These mechanisms involve the modulation ...
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Article
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
The Wiskott–Aldrich syndrome protein (WASP) family of molecules integrates upstream signalling events with changes in the actin cytoskeleton. N-WASP has been implicated both in the formation of cell-surface pr...
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Article
Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy
The hormone leptin has been shown to be an afferent signal in a negative-feedback loop regulating body weight, and consequently, the administration of the gene product for the treatment of obesity has recently...
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Article
Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
When irradiated and administered intradermally as vaccines, cancer cells engineered to secrete high levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) by gene transfer elicit potent anticance...
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Article
Dystrophin expression in the mdx mouse restored by stem cell transplantation
The development of cell or gene therapies for diseases involving cells that are widely distributed throughout the body has been severely hampered by the inability to achieve the disseminated delivery of cells ...
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Article
Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
The cytokine interleukin-3 (IL-3), which can be derived from T cells and other sources, is a potentially important link between the immune and haematopoietic systems1. IL-3 may be particularly critical for the de...
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Article
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
We previously described a method for isolating murine hematopoietic stem cells capable of reconstituting lethally irradiated recipients, which depends solely on dual-wavelength flow cytometric analysis of muri...
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Article
A case report: Immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy
The first use of granulocyte/macrophage-colony-stimulating-factor-transduced, lethally irradiated, autologous melanoma cells as a therapeutic vaccine in a patient with rapidly progressive, widely disseminated...
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Article
Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo
Interleukin-12 (IL-12) is unique amongst cytokines in being a disulfide-linked heterodimer of two separately encoded subunits (p35 and p40). We expressed single chain IL-12 proteins from retroviral constructs ...
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Article
Induction of Antigen-Specific Tumor Immunity by Genetic and Cellular Vaccines against MAGE: Enhanced Tumor Protection by Coexpression of Granulocyte-Macrophage Colony-Stimulating Factor and B7-1
A number of tumors express antigens that are recognized by specific cytotoxic T cells. The normal host immune responses, however, are not usually sufficient to cause tumor rejection. Using appropriate immuniza...
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Article
Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury
CSF-1 expression precedes renal injury in autoimmune MRL-lpr mice and is responsible for macrophage (Mϕ) proliferation and survival in the kidney. By comparison, C3H-lpr mice do not express CSF-1 in the kidney, a...
