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Article
Exogenous control of mammalian gene expression through modulation of RNA self-cleavage
Recent studies on the control of specific metabolic pathways in bacteria have documented the existence of entirely RNA-based mechanisms for controlling gene expression. These mechanisms involve the modulation ...
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Article
Dystrophin expression in the mdx mouse restored by stem cell transplantation
The development of cell or gene therapies for diseases involving cells that are widely distributed throughout the body has been severely hampered by the inability to achieve the disseminated delivery of cells ...
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Article
Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
The cytokine interleukin-3 (IL-3), which can be derived from T cells and other sources, is a potentially important link between the immune and haematopoietic systems1. IL-3 may be particularly critical for the de...
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Article
Physiological consequences of loss of plasminogen activator gene function in mice
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactiva...
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Article
Correction: Negative regulation of human c-fos expression by the retinoblastoma gene product
Nature 346, 668-671 (1990) THIS letter in the 16 August 1990 issue of Nature reported that the protein product of the retinoblastoma susceptibility gene (RB-1) can repress c-fos expression and AP-1 transcripti...
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Article
Negative regulation of human c-fos expression by thes retinoblastoma gene product
INACTIVATION of the retinoblastoma susceptibility gene (RB-1) has been associated with the aetiology of many types of human cancers, leading to the classification of RB-1 as an anti-oncogene or tumour suppressor...
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Article
Lineage-specific expression of a human β-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells
Recombinant retroviral genomes encoding a chromosomal human β-globin gene have been used to transduce murine haematopoietic stem cells in vitro. After permanent engraftment oflethally irradiated recipients with t...
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Article
Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse
An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow t...
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Article
Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome
Rabbit β-globin complementary DNA (cDNA) has been inserted into SV40DNA in place of the gene coding for the virus' major capsid protein, VP1. The recombinant genome, SVGT5-RaβG, multiplies efficiently in CV1 m...