-
Article
Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
Lactylation was initially discovered on human histones. Given its nascence, its occurrence on nonhistone proteins and downstream functional consequences remain elusive. Here we report a cyclic immonium ion of ...
-
Article
Open AccessCorrection to: Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
In the original publication of this article [1], Fig. 3 is wrong, but does not affect discussions and conclusions drawn in the article.
-
Article
Open AccessArtemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
Cancer-associated fibroblasts (CAFs) are activated fibroblasts associated with cancer. They have an important role in tumor growth and metastasis. Artemisinin (ART) is a sesquiterpene lactone extracted from Ch...
-
Article
Open AccessNatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression
N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD promotes the migratory and invasive capabilities of...
-
Article
Open AccessDiptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells
Exploration of a new differentiation therapy that extends the range of differentiation for treating acute myeloid leukemia (AML) is attractive to researchers and clinicians. Here we report that diptoindonesin ...
-
Article
Symbionts, a promising source of bioactive natural products
Symbionts are microorganisms residing in multicellular hosts (e.g., plants and animals), and they have been witnessed to be a rich source of diverse functional molecules. This review describes structures and b...
-
Article
Open AccessInduction of human fetal hemoglobin expression by adenosine-2’,3’-dialdehyde
Pharmacologic reactivation of fetal hemoglobin expression is a promising strategy for treatment of sickle cell disease and β-thalassemia. The objective of this study was to investigate the effect of the methyl...
-
Article
Tn5 transposase-assisted high-efficiency transformation of filamentous fungus Phoma herbarum YS4108
Conventionally, filamentous fungi are transformed by using conidia or protoplasts as recipients. However, induction of sporulation is difficult in some fungi, and protoplasting is an awing, frequently frustrat...
-
Article
Fabrication and properties of a porous chitin/chitosan conduit for nerve regeneration
A porous, biodegradable, natural chitin/chitosan nerve conduit was constructed. Scanning electron microscopy confirmed that it was homogeneous and highly porous. FT-IR spectra showed that there were no residue...
-
Article
Antimicrobial activities of isoalantolactone, a major sesquiterpene lactone ofInula racemosa
Isoalantolactone, a major constituent ofInula racemosa (Compositae) was tested for its antimicrobial action against five bacteria, six human and six plant pathogenic fungi. The lactone showed absolute toxicities ...
-
Article
An acidic polysaccharide with xylose branches fromPorphyra yezoensis
An acidic polysaccharide (PY3) was isolated from the hot water extract of the red algaePorphyra yezoensis by successive column chromatographies over DEAE-cellulose and Sephadex G-200. PY3 with an average molecula...
