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  1. No Access

    Article

    Mesothelin-targeted CAR-T therapy combined with irinotecan for the treatment of solid cancer

    Chimeric antigen receptor (CAR) T cell therapy has shown promising results in treating blood cancers, but it has limited efficacy against solid tumors that express mesothelin (MSLN). One of the reasons is the ...

    Yuankui Zhu, Dianbao Zuo, Ke Wang, Sina Lan… in Journal of Cancer Research and Clinical On… (2023)

  2. Article

    Open Access

    Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells

    Glypican-3 (GPC3) is a cell surface heparan sulfate proteoglycan that is being evaluated as an emerging therapeutic target in hepatocellular carcinoma (HCC). GPC3 has been shown to interact with several extrac...

    Panpan Meng, Yi-Fan Zhang, Wangli Zhang, **n Chen, Tong Xu, Sheng Hu… in Scientific Reports (2021)

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    Article

    Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis

    Glypican-3 is a cell surface glycoprotein that associates with Wnt in liver cancer. We develop two antibodies targeting glypican-3, HN3 and YP7. The first antibody recognizes a functional epitope and inhibits ...

    Wei Gao, Zhewei Tang, Yi-Fan Zhang, Mingqian Feng, Min Qian… in Nature Communications (2015)

  4. No Access

    Article

    Tn5 transposase-assisted high-efficiency transformation of filamentous fungus Phoma herbarum YS4108

    Conventionally, filamentous fungi are transformed by using conidia or protoplasts as recipients. However, induction of sporulation is difficult in some fungi, and protoplasting is an awing, frequently frustrat...

    Mingqian Feng, Tian Zhou, Wenjie Wei… in Applied Microbiology and Biotechnology (2008)