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Article
Open AccessDifferential attainment in assessment of postgraduate surgical trainees: a sco** review
Solving disparities in assessments is crucial to a successful surgical training programme. The first step in levelling these inequalities is recognising in what contexts they occur, and what protected characte...
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Article
Open AccessInterrupting sitting acutely attenuates cardiometabolic risk markers in South Asian adults living with overweight and obesity
This study examined the acute effects of interrupting sitting with light-intensity walking on postprandial cardiometabolic risk markers in South Asian adults.
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Article
Open AccessSexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
Current methods fail to accurately predict women at greatest risk of develo** fetal growth restriction (FGR) or related adverse outcomes, including stillbirth. Sexual dimorphism in these adverse pregnancy ou...
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Article
Open AccessA prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers
Advanced maternal age (≥35 years) is associated with increased rates of adverse pregnancy outcome. Better understanding of underlying pathophysiological processes may improve identification of older mothers wh...
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Article
Open AccessHypoxia and oxidative stress induce sterile placental inflammation in vitro
Fetal growth restriction (FGR) and stillbirth are associated with placental dysfunction and inflammation and hypoxia, oxidative and nitrative stress are implicated in placental damage. Damage-associated molecu...
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Article
Open AccessLater Life Sex and Rubin’s ‘Charmed Circle’
Gayle Rubin’s now classic concept of the ‘charmed circle’ has been much used by scholars of sexuality to discuss the ways in which some types of sex are privileged over others. In this paper, I apply the conce...
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Article
Open AccessPlacental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women
Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth restriction (FGR) and stillbirth. We hypothesised that maternal ageing is associated with utero-placental dysfunction, predis...
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Article
Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy
Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells d...
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Article
Open AccessQuantitative assessment of placental morphology may identify specific causes of stillbirth
Stillbirth is frequently the result of pathological processes involving the placenta. Understanding the significance of specific lesions is hindered by qualitative subjective evaluation. We hypothesised that q...
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Article
The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy
Unique biochemical and physical challenges to both mother and fetus are observed during human pregnancy, and the placenta plays an important role in protecting the fetus and supporting its development. Consequ...
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Article
Open AccessLaser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis
Understanding the pathophysiology of chemokine secretion in endometriosis may offer a novel area of therapeutic intervention. This study aimed to identify chemokines differentially expressed in epithelial glan...
