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Article
Open AccessDifferential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease
Molecular characterization of late-onset Alzheimer’s disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway alterations associated with disease. Assessing th...
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Article
Open AccessGenetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in ...
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Article
Open AccessMolecular characterization of senescence marker protein-30 gene promoter: Identification of repressor elements and functional nuclear factor binding sites
Senescence marker protein-30 (SMP30), whose expression declines during aging in rat liver, has been proposed as an important aging marker. Besides apoptosis, SMP30 also protects cells against various other inj...
