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Article
Open AccessBiomaterial-based sponge for efficient and environmentally sound removal of bacteria from water
Designing materials capable of disinfecting water without releasing harmful by-products is an ongoing challenge. Here, we report a novel polycationic sponge material synthesized from chitosan derivatives and c...
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Article
Open AccessOne to one comparison of cell-free synthesized erythropoietin conjugates modified with linear polyglycerol and polyethylene glycol
With more than 20 Food and Drug Administration (FDA)-approved poly (ethylene glycol) (PEG) modified drugs on the market, PEG is the gold standard polymer in bioconjugation. The coupling improves stability, eff...
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Article
Design of therapeutic biomaterials to control inflammation
Inflammation plays an important role in the response to danger signals arising from damage to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in many diseases, including cancer...
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Article
Open AccessIn vitro efficacy of Artemisia extracts against SARS-CoV-2
Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronaviru...
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Article
Open AccessFunctional Surfactants for Molecular Fishing, Capsule Creation, and Single-Cell Gene Expression
We have demonstrated how to create a parent surfactant that is open to manipulation, while maintaining its surface activity, robustness, and compatibility,...
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Article
Open AccessSynthesis of pH-degradable polyglycerol-based nanogels by iEDDA-mediated crosslinking for encapsulation of asparaginase using inverse nanoprecipitation
Biocompatible, environmentally responsive, and scalable nanocarriers are needed for targeted and triggered delivery of therapeutic proteins. Suitable polymers, preparation methods, and crosslinking chemistries...
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Article
Open AccessModular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
Detergents enable the purification of membrane proteins and are indispensable reagents in structural biology. Even though a large variety of detergents have been developed in the last century, the challenge re...
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Article
Open AccessDendronized fluorosurfactant for highly stable water-in-fluorinated oil emulsions with minimal inter-droplet transfer of small molecules
Fluorosurfactant-stabilized microfluidic droplets are widely used as pico- to nanoliter volume reactors in chemistry and biology. However, current surfactants cannot completely prevent inter-droplet transfer o...
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Article
Open AccessExploring the Potential of Dendritic Oligoglycerol Detergents for Protein Mass Spectrometry
The ability to design detergents that are suitable for protein analysis by mass spectrometry (MS) represents an on-going challenge in the field of native MS. Desirable detergent characteristics include charge-...
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Article
Open AccessPreserving π-conjugation in covalently functionalized carbon nanotubes for optoelectronic applications
Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp2 netwo...
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Article
Open AccessDendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin
Dendritic hPG-amid-C18-mPEG core-multishell nanocarriers (CMS) represent a novel class of unimolecular micelles that hold great potential as drug transporters, e.g., to facilitate topical therapy in skin disea...
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Article
Open AccessInfluence of dendritic polyglycerol sulfates on knee osteoarthritis: an experimental study in the rat osteoarthritis model
Anti-inflammatory nanoparticular compounds could represent a strategy to diminish osteoarthritis (OA) progression.
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Article
Effects of dendritic polyglycerol sulfate on articular chondrocytes
Inflammatory processes driven by cytokines play a crucial role during osteoarthritis (OA) progression. Dendritic polyglycerol sulfate (dPGS) was analyzed in vitro for its effects on articular chondrocytes, car...
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Article
Biodistribution, cellular localization, and in vivo tolerability of 35S-labeled antiinflammatory dendritic polyglycerol sulfate amine
Antiinflammatory dendritic polyglycerol sulfate (dPGS) holds great potential in the treatment and imaging of inflammatory processes. Here, we studied its biokinetic behavior, biodistribution, target cells, an...
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Reference Work Entry In depth
Dendrimers and Hyperbranched Polymers in Medicine
-
Chapter
Dendritic Polymers in Targeted Drug Delivery
have gained significant attention in the last two decades due to their size, shape, and multifunctionality. They have emerged as potential scaffolds for drug delivery applications. This chapter deals with t...
-
Living Reference Work Entry In depth
Dendrimers and Hyperbranched Polymers in Medicine
-
Article
Calix[8]arene Functionalized Polyglycerol Nanogels for Encapsulation and Stabilization of Fluorescent Dyes
In this paper we report on the preparation of calix[8]arene functionalized polyglycerol nanogels by miniemulsion polymerization. The gel macromonomers were prepared by anionic ring-opening multibranching polym...
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Article
Multifunctional Dendritic Architectures: An Investigation of their Mechanical Properties
The paper deals with the synthesis and investigation of mechanical properties of multifunctional polyglycerol nanogels which consist of PEG with different chain lengths (glycerol, PEG 400, PEG 400-DGE, and PEG...
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Chapter
Multivalent Dendritic Architectures for Theranostics
For the past few years, molecular imaging and targeted drug delivery have been playing an important role toward personalized medicine. In designing and fabricating of multifunctional nanoparticles, the combina...
