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  1. Article

    Open Access

    Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

    Many transmembrane receptors have a desensitized state, in which they are unable to respond to external stimuli. The family of microbial rhodopsin proteins includes one such group of receptors, whose inactive ...

    Juan F. Bada Juarez, Peter J. Judge, Suliman Adam, Danny Axford… in Nature Communications (2021)

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  2. Article

    Open Access

    Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

    Detergents enable the purification of membrane proteins and are indispensable reagents in structural biology. Even though a large variety of detergents have been developed in the last century, the challenge re...

    Leonhard H. Urner, Idlir Liko, Hsin-Yung Yen, Kin-Kuan Hoi… in Nature Communications (2020)

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  3. No Access

    Article

    PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

    G-protein-coupled receptors (GPCRs) are involved in many physiological processes and are therefore key drug targets1. Although detailed structural information is available for GPCRs, the effects of lipids on the ...

    Hsin-Yung Yen, Kin Kuan Hoi, Idlir Liko, George Hedger, Michael R. Horrell… in Nature (2018)