![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessA combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells
Cell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs. We recently reported that a peptide derived from the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy...
-
Article
Open AccessAn anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the progression of diabetes, negatively impacting insulin production and secretion from pancreatic cells. In search for a tool ...
-
Article
Open AccessThe two redox states of the human NEET proteins’ [2Fe–2S] clusters
The NEET proteins constitute a unique class of [2Fe–2S] proteins. The metal ions bind to three cysteines and one histidine. The proteins’ clusters exist in two redox states; the oxidized protein (containing tw...
-
Article
Cryo-EM photosystem I structure reveals adaptation mechanisms to extreme high light in Chlorella ohadii
Photosynthesis in deserts is challenging since it requires fast adaptation to rapid night-to-day changes, that is, from dawn’s low light (LL) to extreme high light (HL) intensities during the daytime. To under...
-
Article
Open AccessIntegration of photocatalytic and dark-operating catalytic biomimetic transformations through DNA-based constitutional dynamic networks
Nucleic acid-based constitutional dynamic networks (CDNs) have recently emerged as versatile tools to control a variety of catalytic processes. A key challenge in the application of these systems is achieving ...
-
Article
Open AccessThe cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans
Programmed cell death, which occurs through a conserved core molecular pathway, is important for fundamental developmental and homeostatic processes. The human iron–sulfur binding protein NAF-1/CISD2 binds to ...
-
Article
Open AccessThe unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease
NEET proteins comprise a new class of [2Fe-2S] cluster proteins. In human, three genes encode for NEET proteins: cisd1 encodes mitoNEET (mNT), cisd2 encodes the Nutrient-deprivation autophagy factor-1 (NAF-1) and...
-
Article
Open AccessPhylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin
The iron-sulfur (2Fe-2S) binding motif CDGSH appears in many important plant and animal proteins that regulate iron and reactive oxygen metabolism. In human it is found in CISD1-3 proteins involved in diabetes...
-
Article
Open AccessPhylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates
NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the “NEET” motif. They are involved in the regulation of iron an...
-
Article
Correction: Corrigendum: Assembly of photo-bioelectrochemical cells using photosystem I-functionalized electrodes
Nature Energy 1, 15021 (2016); published 18 January 2016; corrected 28 January 2016. In the version of this Article originally published, an author's name contained a typographical error and should have read S...
-
Article
Assembly of photo-bioelectrochemical cells using photosystem I-functionalized electrodes
The design of photo-bioelectrochemical cells based on native photosynthetic reaction centres is attracting substantial recent interest as a means for the conversion of solar light energy into electrical power....
-
Article
Photosynthetic reaction center-functionalized electrodes for photo-bioelectrochemical cells
During the last few years, intensive research efforts have been directed toward the application of several highly efficient light-harvesting photosynthetic proteins, including reaction centers (RCs), photosyst...
-
Article
Integrated photosystem II-based photo-bioelectrochemical cells
Photosynthesis is a sustainable process that converts light energy into chemical energy. Substantial research efforts are directed towards the application of the photosynthetic reaction centres, photosystems I...
-
Chapter
The Assembly of Photosystem I Reducing Site
This chapter underlines the knowledge accumulated on the assembly of the reducing site of Photosystem I (PS I). A brief description of the biochemical and molecular characteristics of the reducing-site members...
-
Chapter
Introduction to Photosystem I: Reaction Center Function, Composition and Structure
-
Article
The carboxyl-terminal region of the spinach PsaD subunit contains information for its specific assembly into plant thylakoids
The assembly of the multi-subunit membrane-protein Photosystem I (PS I) complex involves incorporation of peripheral proteins into the complex. Here we studied assembly of the PsaD subunit of the cyanobacteria...
-
Article
Assembly of the chlorophyll-protein complexes
The biogenesis of photosynthetic complexes in plants and algae is a multi-step process that involves intricate coordination of steps in two intracellular compartments, the chloroplast and the cytoplasm. The pr...
-
Article
Function and organization of Photosystem I polypeptides
Photosystem I functions as a plastocyanin:ferredoxin oxidoreductase in the thylakoid membranes of chloroplasts and cyanobacteria. The PS I complex contains the photosynthetic pigments, the reaction center P700...
-
Article
Stable assembly of PsaE into cyanobacterial photosynthetic membranes is dependent on the presence of other accessory subunits of photosystem I
We studied assembly of the PsaE subunit of photosystem I into photosynthetic membranes of cyanobacterial mutant strains that lack specific photosystem I subunits. Radiolabeled PsaE was incubated with photosynt...
-
Article
Subunit III (Psa-F) of photosystem I reaction center of the C4 dicotyledon Flaveria trinervia
An immunological survey of C3, C4 and C3-C4-intermediate Flaveria species showed that subunit III (PsaF) of the photosystem I reaction center (PSI-RC) is present in all these species. This was confirmed by the is...