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Open AccessDetecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing
The Oxford Nanopore (ONT) platform provides portable and rapid genome sequencing, and its ability to natively profile DNA methylation without complex sample processing is attractive for point-of-care real-time...
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Article
Open AccessAuthor Correction: Clinical Implications of Sub-grou** HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessClinical Implications of Sub-grou** HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes
ERBB2 amplification is a prognostic marker for aggressive tumors and a predictive marker for prolonged survival following treatment with HER2 inhibitors. We attempt to sub-group HER2+ tumors based on amplicon str...
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Open AccessErratum to: ‘Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells’
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Article
Open AccessPhosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells
The SWI/SNF ATP dependent chromatin remodeling complex is a multi-subunit complex, conserved in eukaryotic evolution that facilitates nucleosomal re-positioning relative to the DNA sequence. In recent years th...
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Article
Centrosome Amplification and Chromosomal Instability in Human and Animal Parthenogenetic Cell Lines
Parthenotes have been proposed as a source of embryonic stem cells but they lack the centriole which is inherited through the sperm in all mammalian species, except for rodents. We investigated the centrosome ...
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Article
Differentiation of Human Embryonic Stem Cells into Embryoid Bodies Comprising the Three Embryonic Germ Layers
Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were demonstrated to be true pluripotent cells as they differentiate into all embryonic lineages. Yet, in vi...
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Introduction to Photosystem I: Reaction Center Function, Composition and Structure