4 Result(s)
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Henri-Baptiste Marjault
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Article
Open AccessA combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells
Cell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs. We recently reported that a peptide derived from the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy...
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Article
Open AccessAn anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the progression of diabetes, negatively impacting insulin production and secretion from pancreatic cells. In search for a tool ...
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Article
Open AccessThe two redox states of the human NEET proteins’ [2Fe–2S] clusters
The NEET proteins constitute a unique class of [2Fe–2S] proteins. The metal ions bind to three cysteines and one histidine. The proteins’ clusters exist in two redox states; the oxidized protein (containing tw...
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Article
Open AccessThe unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease
NEET proteins comprise a new class of [2Fe-2S] cluster proteins. In human, three genes encode for NEET proteins: cisd1 encodes mitoNEET (mNT), cisd2 encodes the Nutrient-deprivation autophagy factor-1 (NAF-1) and...
