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Chapter
An Integrated Gas Chromatographic-Mass Spectrometric Screening Method for Anabolic Steroid Urinary Metabolites in Man
For at least 3000 years, it has been a common practice to use various substances in attempts to increase physical prowess1. Since the mid-1970’s, an upsurge in the use of anabolic steroids has occured, due in par...
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Chapter
Lung Carcinogenesis During in Vivo Cigarette Smoking and Radon Daughter Exposure in Rats
The carcinogenic activity of tobacco smoke is clearly demonstrated by human epidemiologic data. Whereas in experimental animals tracheobronchial applications or injections of tars produce cancerous lesions, in...
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Chapter
Modulation of Tumor Growth and Metastasis by an Acute Inflammation
Many studies have led to the conclusion that macrophage can contribute in a variety of ways to host resistance against tumors. Non immune inflammation represents the major mechanism by which indirect activatio...
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Chapter
Effect of an acute inflammatory process on tumour development
Since the pioneer work of Metchnikoff it has become well established that a non-immunological inflammation can increase host resistance against infection1. However, little is known about the efffect of such an in...
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Chapter
Effect of tumour growth on inflammatory macrophages
Studies in many laboratories have led to the speculation that macrophages probably play a significant role in host defence against neoplasia. It has been shown both in vitro and in vivo that macrophages can destr...
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Chapter
Respiratory Carcinogenesis in Rats after Inhalation of Radioactive Aerosols of Actinides and Lanthanides in Various Physicochemical Forms
To study the role of the distribution of local tissue irradiation on the toxicity of alpha emitters, groups of 50 to 165 rats were exposed to aerosols of 244Cm(NO3)3, 241Am(NO3)3, 238Pu(NO3)4, 235Pu(NO3)4, 239PuO
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Chapter
Lesions and Lung Cancers Induced in Rats by Inhaled Radon 222 at Various Equilibriums with Radon Daughters
To investigate the dose-effect relationships, rats were exposed to several dose levels of radon at different levels of equilibrium with radon decay products, after inhalation of stable cerium hydroxide, and in...